Who is sponsoring NCT06617338?

NCT06617338 is sponsored by University of Louisville.

What drugs are being tested in NCT06617338?

Interventions in NCT06617338: CT scan unilateral knee, CT scan bilateral knee.

What condition does NCT06617338 study?

NCT06617338 studies Osteoarthritis (OA) of the Knee.

Is NCT06617338 still recruiting?

NCT06617338 is currently terminated. Last updated 25 March 2026.

Last reviewed 2026-03-25 · How we verify

NCT06617338

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Native Alignment in the Setting of an Arthritic Knee in Total Knee Arthroplasty

Terminated NA Last updated 25 March 2026

What this trial tests

NA trial testing CT scan unilateral knee in Osteoarthritis (OA) of the Knee in 1 participant. Terminated before completion.

Timeline

12 December 2024

Primary endpoint
27 February 2026

2 March 2026

Quick facts

Lead sponsor	University of Louisville
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	basic science
Enrollment	1
Start date	12 December 2024
Primary completion	27 February 2026
Estimated completion	2 March 2026
Sites	1 location across United States

Drugs / interventions tested

CT scan unilateral knee
CT scan bilateral knee

Conditions studied

Osteoarthritis (OA) of the Knee — all drugs for Osteoarthritis (OA) of the Knee →

Sponsor

University of Louisville

Who can join

Adults 21 to 89, any sex, with Osteoarthritis (OA) of the Knee. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this clinical trial is to learn if preparing the target alignment of the operative side in total knee arthroplasty (TKA) based on the non-arthritic side will give the patient better overall alignment, function, and improved results compared to basing our implant alignment and positioning off the arthritic side, which is currently the traditional method. The main questions it aims to answer are: * Will a patient have improved postoperative TKA results if the implant alignment is based off the non-arthritic side compared to the standard arthritic side? * What are the similarities or differences between study arms with respect to final implant alignment and positioning angles? Researchers will compare the outcomes of two cohorts of patients undergoing primary robotic-assisted total knee arthroplasty (RA-TKA) with normal contralateral knee. Based on preoperative CT imaging, the researchers will use normal contralateral side joint numbers as the target alignment for one group (Experimental arm) and utilize the traditional method for the other group (Active comparator arm). Clinical outcomes and patient-reported outcome measures (PROMs) will be compared between groups. Participants will: * Be randomized into one of two study arms and will receive either a unilateral knee CT or bilateral knee CT preoperatively * Follow-up in the clinic at 2 weeks, 6 weeks and 1-year postoperatively, per standard-of-care for x-ray and clinical evaluation. * Complete postop questionnaires (PROMs) at the prescribed follow-up intervals

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Osteoarthritis (OA) of the Knee

Currently open trials in the same condition.

NCT07231471 — Platelet Rich Plasma for Musculoskeletal Conditions · NA · recruiting
NCT06929871 — Mako Cementless TKA vs Mako Cemented TKA · NA · recruiting
NCT06865079 — 53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe Tibio-Femo · Phase 2 · active not recruiting
NCT06702046 — The Efficacy of Transcutaneous Pulsed Radiofrequency Acupuncture for Knee Osteoarthritis · NA · recruiting
NCT06805188 — Clinical Study of Acupuncture Treatment of Knee Osteoarthritis · NA · recruiting

Other University of Louisville trials

Trials by the same sponsor.

NCT07219888 — Comparison of Suzetrigine and Oxycodone for Postoperative Pain After Primary Total Knee Arthroplasty · Phase 4 · not yet recruiting
NCT07044726 — Betadine vs Sterile Water for Periurethral Preparation · Phase 4 · not yet recruiting
NCT06489106 — Noninvasive Spinal Stimulation to Restore Hand Function in Children With Spinal Cord Injury · NA · enrolling by invitation
NCT06883513 — Osteopathic Manipulative Therapy Effects on Post-Acute Sequelae of COVID-19 (PASC) or Long COVID · NA · recruiting
NCT05920720 — Self-Guided Personalized Treatment for Women · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06617338 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Louisville
Last refreshed: 25 March 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06617338.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing