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NCT06584526
Effects of Aerobic and Strength Exercice on Nociplastic Pain in Temporomandibular Disorders
NA trial testing Physical Therapy in Temporomandibular Disorders (TMD) in 51 participants. Not yet recruiting.
31 July 2025
Quick facts
| Lead sponsor | Universitat Internacional de Catalunya |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 51 |
| Start date | 9 September 2024 |
| Primary completion | 31 July 2025 |
| Estimated completion | 31 July 2025 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Physical Therapy
- Physical Therapy and Aerobic Exercise
- Physical Therapy and Strength Exercise
Conditions studied
- Temporomandibular Disorders (TMD) — all drugs for Temporomandibular Disorders (TMD) →
- Nociplastic Pain — all drugs for Nociplastic Pain →
- Aerobic Exercise — all drugs for Aerobic Exercise →
- Strengthening Exercises — all drugs for Strengthening Exercises →
Sponsor
Universitat Internacional de Catalunya — full company profile →
Who can join
Adults 18 to 55, any sex, with Temporomandibular Disorders (TMD) or Nociplastic Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Chronic temporomandibular disorders are common in the general population. Nociplastic pain seems to be present in this pathology, with an hypersensitivity to touch, pressure and movement observed in both local and remote areas, as weel as comorbidities such as fatigue, sleep disturbance, difficulty to focus attention and memory disturbance. The best evidence-based treatment of temporomandibular disorders consists in combining education, manual therapy and therapeutic exercise in both temporomandibular and cervical regions. Aerobic and strength exercises showed to be effective in subjects with chronic pain and nociplastic pain, by inducing an hypoalgesic effect. However, there isn\'t investigation about the effects of theses types of exercise in subjects with temporomandibular disorders and nociplastic pain. Thus, the aim of the study is to determine if adding aerobic or strength exercise to an effective physical therapy programme is more effective than physical therapy alone to improve nociplastic pain in subjects with temporomandibular disorders.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Association Between Nociplastic Pain Criteria and Clinical and Physiological Features in Temporomandibular Disorders: A Cross-Sectional Study.
Dantony F, Romero-Rodríguez D, Blanco D, Zárate-Tejero CA, et al · · 2025 · PMID 41464867 · DOI 10.3390/jcm14248967
Verify or expand the search:
- PubMed search for NCT06584526
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Temporomandibular Disorders (TMD)
Currently open trials in the same condition.
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Other Universitat Internacional de Catalunya trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06584526 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universitat Internacional de Catalunya
- Last refreshed: 4 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06584526.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing