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NCT06578234: HYPER
Hyperemic mYocardial Perfusion by adEnosine at diffeRent Doses
Phase 4 trial testing Adenosine in Chronic Coronary Syndrome in 180 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | Region Skane |
|---|---|
| Phase | Phase 4 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | diagnostic |
| Enrollment | 180 |
| Start date | 23 October 2024 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Adenosine (ADENOSINE) — full drug profile →
Conditions studied
- Chronic Coronary Syndrome — all drugs for Chronic Coronary Syndrome →
- Coronary Artery Disease — all drugs for Coronary Artery Disease →
- Ischemic Heart Disease — all drugs for Ischemic Heart Disease →
Sponsor
Region Skane — full company profile →
Who can join
40 and older, any sex, with Chronic Coronary Syndrome or Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Adenosine is a commonly used pharmaceutical stressor at cardiac magnetic resonance examinations to assess suspected chronic coronary syndrome (CCS). However, several studies have reported that the current use of adenosine does not induce adequate hyperemic response in a substantial number of patients, leading to false diagnostics. The aim of this trial is to investigate the hyperemic effect of the standard dose of adenosine (140 microgram/kg/min) to the high dose of adenosine (210 microgram/kg/min) to improve the diagnostic methods using adenosine as a stressor and ultimately improve treatment decisions and patient prognosis in CCS.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06578234
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Region Skane trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06578234 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Region Skane
- Last refreshed: 27 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06578234.
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