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NCT07291609: CCS-Plastics
Microplastics and Nanoplastics in Patients With Chronic Coronary Syndromes
trial in Chronic Coronary Syndrome in 120 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | Azienda Ospedaliera "Sant'Andrea" |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 120 |
| Start date | 1 September 2025 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2029 |
| Sites | 6 locations across Italy |
Conditions studied
- Chronic Coronary Syndrome — all drugs for Chronic Coronary Syndrome →
- Microplastics — all drugs for Microplastics →
- Nanoplastics — all drugs for Nanoplastics →
- Coronary Artery Disease — all drugs for Coronary Artery Disease →
Sponsor
Azienda Ospedaliera "Sant'Andrea" — full company profile →
Who can join
18 and older, any sex, with Chronic Coronary Syndrome or Microplastics. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The CCS-plastics is an investigator-initiated, prospective, multicenter study of patients undergoing coronary CT angiography (CCTA) for suspected or known chronic coronary syndromes (CCS) referred to invasive coronary angiography for clinical indication. Patients identified as eligible for the protocol will be asked for written consent to participate in the study. The patients' dossiers will be uploaded and transmitted to the core laboratory for analysis. The routine management of the CCS patients will not be affected and all patients will be managed according to current standards. Invasive coronary angiography and coronary blood samples will be performed following the current standards, guidelines, and indications. During invasive coronary angiography, coronary blood samples will be collected per standard of care and sent to a centralized, specialized core laboratory for MNPs and biomarkers analysis. The central core lab for MNPs analyses will be the University of Campania Luigi Vanvitelli, Naples, Italy. The identification, quantification (concentration, mcg/ml), and typing of plastic particles will be performed in each tube for each patient, using pyrolysis-gas chromatography-mass spectrometry (Py-GC/MS) and laser direct infrared (LDIR) spectroscopy. The CCTA will be centrally analyzed by Centro Cardiologico Monzino to evaluate qualitative and quantitative plaque features. Patients will be followed clinically at 1 and 3 years per standard of care.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07291609
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Azienda Ospedaliera "Sant'Andrea" trials
Trials by the same sponsor.
- NCT06965023 — Microplastics and Nanoplastics (MNPs) in Patients With ST-elevation Myocardial Infarction (STEMI) · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07291609 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Azienda Ospedaliera "Sant'Andrea"
- Last refreshed: 18 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07291609.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing