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NCT06550414
Dexmedetomidine As An Adjuvant To Bupivacaine 0.1% in Labor Analgesia
NA trial testing Dexmedetomidine in Labor Analgesia in 165 participants. Completed in 1 May 2023.
1 April 2023
Quick facts
| Lead sponsor | Services Institute of Medical Sciences, Pakistan |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | other |
| Enrollment | 165 |
| Start date | 1 November 2022 |
| Primary completion | 1 April 2023 |
| Estimated completion | 1 May 2023 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- Dexmedetomidine (dexmedetomidine) — full drug profile →
- Bupivacain — full drug profile →
Conditions studied
- Labor Analgesia — all drugs for Labor Analgesia →
- Labor Pain — all drugs for Labor Pain →
Sponsor
Services Institute of Medical Sciences, Pakistan
Who can join
Adults 20 to 40, female only, with Labor Analgesia or Labor Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Females who have experienced normal labor for child birth have claimed it to be most difficult and distressing moments of their life due to excruciating and unbearable pain. Provision of effective and satisfactory labor analgesia to the parturient helps in achieving greater degree of well-being for both mother and child. Several medical and non-medical pain relief methods are used since ages for pain relief during childbirth. Epidural anesthesia and intravenous opioids (pethidine) are most commonly offered to the mothers for relieving labor pain. So far, Epidural is considered gold standard in attaining maternal satisfaction for pain free deliveries. lt can be modified for individual parturient in order to achieve highest level of comfort and pain relief. To attain better and prolonged analgesia several additives have been used with local anesthetists and their effects are studied. Epidural opioids are conventionally being used as adjuvants, however associated side effects (nausea, vomiting, and pruritus) may limit their use. An alpha 2 adrenoceptor agonist, dexmedetomidine, has been effectively used and studied in labor epidurals and provided better analgesia without significant side effects. Hamed Lateef Hospital is one of the largest tertiary care private setup offering painless deliveries in Lahore. It is need of the hour to modify and improve our clinical practice in order to achieve highest level of patient satisfaction and provision of best possible maternal and fetal outcome. This study is proposed to investigate and elaborate the effect of adding dexmedetomidine to bupivacaine in labor epidurals and to study possible side-effects associated with its use.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06550414
- Europe PMC full search
- ASCO Meeting Library
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- bioRxiv preprints
- medRxiv preprints
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Related trials
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Trials testing the same drug.
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- NCT07377981 — An Exploratory Study of the Efficacy and Safety of Esketamine and Dexmedetomidine in Non-Intubated ICU Patients With Hyp · Phase 4 · not yet recruiting
- NCT07306702 — Dexmedetomidine-Enhanced PCIA After Lobectomy in Nicotine-Dependent Patients · Phase 4 · withdrawn
- NCT07482540 — Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery · NA · not yet recruiting
Other recruiting trials for Labor Analgesia
Currently open trials in the same condition.
- NCT07076368 — Ropivacaine and Fentanyl for Labor Epidural Initiation · Phase 3 · recruiting
- NCT07083167 — Anesthesia Clinical Practice During Labour Neuraxial Analgesia · recruiting
- NCT06602440 — Effect of Epidural Catheter Retention Depth on Labor Analgesia Performed in DPE Combined With PIEB Model · NA · recruiting
- NCT06300151 — The Effect of Ultrasound Real-time Guidance Technique on the Effectiveness and Safety of Labor Analgesia · NA · recruiting
Other Services Institute of Medical Sciences, Pakistan trials
Trials by the same sponsor.
- NCT07274319 — EFFICACY OF TRANSMUCOSAL MINIPLEITE STABILIZATION TECHNIQUE VERSUS INTRA-ARCH WIRE STABILIZATION TECHNIQUE FOR FIXATION · NA · not yet recruiting
- NCT07238946 — Musculoskeletal Pain and Its Association With Stress in Medical Students · completed
- NCT06720051 — Intraosseous Versus Submucosal Dexamethsone Injection in Third Molar Surgery · NA · not yet recruiting
- NCT07243977 — Comparison of Microneedling Along With Topical Vitamin D3 Versus Microneedling in Alopecia Areata · NA · active not recruiting
- NCT06622642 — Efficacy of Transoral Versus Transbuccal Technique for Fixation of Mandibular Angle Fracture · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06550414 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Services Institute of Medical Sciences, Pakistan
- Last refreshed: 13 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06550414.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing