Last reviewed · How we verify
NCT06525987: TELECONNECT
Telecoached Exercise Intervention for Connectivity Enhancement in Small Vessel Disease (TELECONNECT-SVD)
NA trial testing Physical activity in Lacunar Stroke in 60 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | University of L'Aquila |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 2 May 2025 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Physical activity
Conditions studied
- Lacunar Stroke — all drugs for Lacunar Stroke →
- Small Vessel Cerebrovascular Disease — all drugs for Small Vessel Cerebrovascular Disease →
Sponsor
University of L'Aquila
Who can join
60 and older, any sex, with Lacunar Stroke or Small Vessel Cerebrovascular Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The TELECONNECT-SVD study is a prospective, randomized, multicenter trial aimed at testing the efficacy of a remotely delivered exercise protocol on brain functional connectivity in patients with small vessel disease (SVD)-related ischemic stroke. The study will recruit patients aged ≥60 with a history of lacunar stroke, minimal disability (modified Rankin Scale score 0-1), and low physical activity levels. The trial will include 60 participants randomized 1:1 to either a 24-week telecoached exercise intervention or usual care. The exercise program consists of multicomponent physical exercises delivered remotely twice a week. Assessments will be conducted at baseline, 12 weeks, 24 weeks, and 48 weeks. Primary outcomes include changes in brain functional connectivity assessed by high-density EEG and improvements in physical fitness measured by the Senior Fitness Test. Secondary outcomes encompass changes in physical activity levels, anthropometric measurements, and vital signs. The study employs a "wait list" design, where the control group receives the intervention after the initial 24-week period. This approach allows for assessment of the intervention's immediate effects and the retention of benefits after cessation. Key features of the protocol include: * Use of telecoaching to enhance adherence to the exercise program * Comprehensive assessment of brain connectivity using advanced EEG analysis techniques * Focus on patients with SVD, who may benefit significantly from exercise interventions * Evaluation of both neurophysiological and clinical outcomes The study aims to provide evidence for the potential benefits of exercise in enhancing brain connectivity and physical fitness in SVD patients, potentially informing future treatment guidelines and preventive strategies for this population.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06525987
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Physical activity
Trials testing the same drug.
- NCT07363616 — Pilot Test of Five Weight Neutral Interventions to Improve Health Among Adults of Higher Body Weight · NA · recruiting
- NCT07104669 — Sports Nutrition Assessment Program · not yet recruiting
- NCT06541977 — A New Model of Exercise Referral Scheme Before and After Bariatric Surgery for People With Obesity · NA · not yet recruiting
- NCT06817980 — Disorders of the Sense of Self and Physical Activity · NA · not yet recruiting
- NCT07140536 — The Impact of Treadmills and Cooler Environments for Office Workplaces on Ergonomics, Heating Energy Requirements, Perfo · NA · completed
Other recruiting trials for Lacunar Stroke
Currently open trials in the same condition.
- NCT07111559 — Lacunar Stroke hyperAcute Clinical Utilization of Novel Approach Regimens: Rt-PA vs. DAPT Randomised Clinical Trial · Phase 4 · recruiting
- NCT07353424 — A Multicenter Randomized Clinical Trial Compared With Standard Clinical Practice to Evaluate the Efficacy of a Polypheno · NA · recruiting
- NCT06416371 — Retinal Vessel Leakage in Cerebral Small Vessel Disease · recruiting
Other University of L'Aquila trials
Trials by the same sponsor.
- NCT06823466 — Advancing Knowledge in Ischemic Stroke Patients on Oral Anticoagulants · recruiting
- NCT05816213 — Point-of-care Low-field MRI in Acute Stroke · not yet recruiting
- NCT06958874 — Adjunctive Effect of Erythritol on Pocket Closure Rates · NA · recruiting
- NCT06790459 — Effects of the Ultra-low Frequencies TENS on the Arousal Circuits · NA · completed
- NCT06341439 — Clinical Efficacy of Mouthrinses Based on Chlorhexidine 0.12% and CITROX® · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06525987 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of L'Aquila
- Last refreshed: 2 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06525987.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing