Last reviewed · How we verify
NCT06375213: INDE
Investigating Neurocognitive Disorders Epidemiology
trial testing Plasma tau phosphorylated at Thr217 in Dementia in 990 participants. Currently enrolling.
24 August 2035
Quick facts
| Lead sponsor | King Chulalongkorn Memorial Hospital |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 990 |
| Start date | 24 August 2023 |
| Primary completion | 24 August 2035 |
| Estimated completion | 24 August 2035 |
| Sites | 1 location across Thailand |
Drugs / interventions tested
- Plasma tau phosphorylated at Thr217
- Neurocognitive examination
Conditions studied
- Dementia — all drugs for Dementia →
- Cognitive Decline — all drugs for Cognitive Decline →
- Alzheimer Disease — all drugs for Alzheimer Disease →
Sponsor
King Chulalongkorn Memorial Hospital
Who can join
35 and older, any sex, with Dementia or Cognitive Decline. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a prospective cohort study with the main purpose of predicting progression neurocognitive disorders in Thai population. The main predictor variables to be evaluated are plasma phosphorylated tau (p-tau) level and cognitive test scores, which will be combined using statistical/computational modeling. Additionally, it seeks to evaluate biomarkers for diagnosing disease pathologies, understand their correlation with clinical outcomes, and explore the socioeconomic impact of neurocognitive disorders. The study invites both participants for biospecimen collection, structured interviews, and cognitive examinations and schedules follow-up visits annually or biennially.
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
Revisiting the therapeutic landscape of tauopathies: assessing the current pipeline and clinical trials.
Harris GA, Hirschfeld LR, Gonzalez MI, Pritchard MC, et al · · 2025 · cited 8× · PMID 40462159 · DOI 10.1186/s13195-025-01775-x -
Exploring kidney function thereshole for plasma p‐tau 217 use
Haethaisong T, Chongsuksantikul A, Oangkhana P, Luechaipanit W, et al · · 2025 -
Performance of Cognitive Screening Tests for Alzheimer's Disease Pathology Defined by Plasma p‐tau217: A Prospective Cohort Study in Early Dementia Patients at King Chulalongkorn Memorial Hospital, Thailand
Sarutikriangkri Y, Pongpitakmetha T, Hiransuthikul A, Rak‐areekul T, et al · · 2025 -
The Impact of Physical Activity on Cognitive Function in Alzheimer's Disease Diagnosed with Plasma p‐tau 217 in Thailand, a middle income country: A Cross‐Sectional Study
Rak‐areekul T, Chongsuksantikul A, Oangkhana P, Luechaipanit W, et al · · 2025 -
The Effect of Social Determinants of Health on Cognitive Resilience to Alzheimer's Disease, Determined by Plasma p‐tau217 in the Prospective INDE Cohort in Thailand: A Story from a Middle‐Income Country
Taweephol T, Pongpitakmetha T, Hiransuthikul A, Booncharoen K, et al · · 2025
Verify or expand the search:
- PubMed search for NCT06375213
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06375213 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by King Chulalongkorn Memorial Hospital
- Last refreshed: 22 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06375213.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing