Last reviewed · How we verify
NCT06333002: MEMORIAL
Machine Learning Model to Predict Outcome in Acute Hypoxemic Respiratory Failure
trial testing machine learning analysis in Acute Hypoxemic Respiratory Failure in 1,241 participants. Participants enrolled and being followed up; not accepting new ones.
30 May 2026
Quick facts
| Lead sponsor | Dr. Negrin University Hospital |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 1,241 |
| Start date | 19 March 2024 |
| Primary completion | 30 May 2026 |
| Estimated completion | 30 May 2026 |
| Sites | 8 locations across Spain |
Drugs / interventions tested
- machine learning analysis
Conditions studied
- Acute Hypoxemic Respiratory Failure — all drugs for Acute Hypoxemic Respiratory Failure →
Sponsor
Dr. Negrin University Hospital
Who can join
Adults 18 to 100, any sex, with Acute Hypoxemic Respiratory Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Acute hypoxemic respiratory failure (AHRF) is the most common cause of admission in the intensive care units (UCIs) worldwide. We will assess the value of machine learning (ML) techniques for early prediction of ICU death in 1,241 patients enrolled in the PANDORA (Prevalence AND Outcome of acute Respiratory fAilure) Study in Spain. The study was registered with ClinicalTrials.gov (NCT03145974). Our aim is to evaluate the minimum number of variables models using logistic regression and four supervised ML algorithms: Random Forest, Extreme Gradient Boosting, Support Vector Machine and Multilayer Perceptron.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Early Prediction of ICU Mortality in Patients with Acute Hypoxemic Respiratory Failure Using Machine Learning: The MEMORIAL Study.
Villar J, González-Martín JM, Fernández C, Añón JM, et al · · 2025 · cited 1× · PMID 40095813 · DOI 10.3390/jcm14051711
Verify or expand the search:
- PubMed search for NCT06333002
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of machine learning analysis
Trials testing the same drug.
- NCT05611177 — Predicting ICU Mortality in ARDS Patients · completed
Other recruiting trials for Acute Hypoxemic Respiratory Failure
Currently open trials in the same condition.
- NCT07334379 — Interleukin-6 Guided Treatment With Dexamethasone or Tocilizumab in Patients Hospitalized With Acute Respiratory Symptom · Phase 2 · recruiting
- NCT06921655 — Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation · NA · recruiting
- NCT06931938 — Awake Prone Positioning in Spontaneous Breathing Patients With Acute Hypoxic Respiratory Failure Due to Pneumonia · NA · recruiting
- NCT07178483 — Evaluation of Physical Capacity and Energy Requirements in Patients With Hypoxemic Acute Respiratory Failure · active not recruiting
- NCT06815523 — Prediction of Duration of Mechanical Ventilation in Acute Hypoxemic Respiratoty Failure · active not recruiting
Other Dr. Negrin University Hospital trials
Trials by the same sponsor.
- NCT07131228 — Changes in Portal Vein Pulsatility Variability During a Tidal Volume Challenge Can Predict Fluid Tolerance · not yet recruiting
- NCT06857513 — Post-ICU Syndrome Over Time in Patients With Respiratory Failure · not yet recruiting
- NCT06785389 — Influence of Preoperative Fear on Pain and Postoperative Outcomes · recruiting
- NCT06635915 — Ultrasound to Check the Position of the Nasogastric Tube · NA · recruiting
- NCT06386354 — Residual Neuromuscular Block in the Post-Anesthetic Unit and Postoperative Complications · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06333002 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Dr. Negrin University Hospital
- Last refreshed: 11 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06333002.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing