NCT06318130 (LEAD-LBBP) is a NA clinical trial of Fixed helix, lumenless pacing lead. in Pacemaker DDD, sponsored by National University Hospital, Singapore.

Who is sponsoring NCT06318130?

NCT06318130 is sponsored by National University Hospital, Singapore.

What drugs are being tested in NCT06318130?

Interventions in NCT06318130: Fixed helix, lumenless pacing lead., Extendable helix, stylet-driven pacing lead..

What condition does NCT06318130 study?

NCT06318130 studies Pacemaker DDD.

Is NCT06318130 still recruiting?

NCT06318130 is currently active, enrolled. Last updated 6 June 2025.

Last reviewed 2025-06-06 · How we verify

NCT06318130: LEAD-LBBP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison of Pacing Lead Design on Left Bundle Branch Pacing Outcomes: The LEAD_LBBP Randomized Clinical Trial

Active, enrolled NA Last updated 6 June 2025

What this trial tests

NA trial testing Fixed helix, lumenless pacing lead. in Pacemaker DDD in 210 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 January 2023

Primary endpoint
19 October 2025

19 October 2025

Quick facts

Lead sponsor	National University Hospital, Singapore
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	210
Start date	1 January 2023
Primary completion	19 October 2025
Estimated completion	19 October 2025
Sites	1 location across Singapore

Drugs / interventions tested

Fixed helix, lumenless pacing lead.
Extendable helix, stylet-driven pacing lead.

Conditions studied

Pacemaker DDD — all drugs for Pacemaker DDD →

Sponsor

National University Hospital, Singapore

Who can join

21 and older, any sex, with Pacemaker DDD. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This trial seeks to evaluate the performance of the extendable helix, stylet-driven pacing lead (SDL) compared to the fixed helix, lumenless pacing lead (LLL) during left bundle branch pacing (LBBP), with respect to enduring left bundle branch capture on follow-up, incidence of acute lead failure, pacing characteristics including QRS duration, pacing thresholds, R-wave amplitudes and lead impedance, and finally, safety profile during LBBP implantation. These data will guide future lead selection during LBBP implantation in achieving improved procedural success and optimal lead performance.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Pacemaker DDD

Currently open trials in the same condition.

NCT06937658 — Remote Alert Pathway To Optimize CaRe of Cardiac Implantable Electrical Devices · NA · recruiting
NCT06371846 — Comparative Study of the Surface Electrocardiogram Signals During the Implantation of Conduction System Pacing Devices · recruiting
NCT05015660 — Conduction System Pacing With Left Bundle Branch Pacing as Compared to Standard Right Ventricular Pacing · NA · recruiting
NCT04416958 — Pacing to Maintain Physiologic Ventricular Activation · recruiting

Other National University Hospital, Singapore trials

Trials by the same sponsor.

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NCT07460505 — Mandibular Advancement to Reduce Ventricular Load and Improve Quality-of-life in Heart Failure · NA · not yet recruiting
NCT07319676 — Antigen Targeted T Cell Therapy for Relapsed/Refractory B Cell Lymphomas · Phase 1, PHASE2 · recruiting
NCT06983769 — CPAP vs MAD for OSA in Patients With Cognitive Impairment. A Randomized Clinical Trial · NA · recruiting
NCT07091175 — Dupilumab Therapy in Nephrotic Syndrome in Children · Phase 2 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06318130 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by National University Hospital, Singapore
Last refreshed: 6 June 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06318130.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing