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NCT06264063: D-DIST
Study of Behavioral Dysfunctions and Related Neuronal Correlates in Patients With Dystonia
NA trial testing control group in Dystonia in 102 participants. Completed in 10 October 2025.
10 March 2024
Quick facts
| Lead sponsor | IRCCS Centro Neurolesi Bonino Pulejo |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | screening |
| Enrollment | 102 |
| Start date | 10 January 2024 |
| Primary completion | 10 March 2024 |
| Estimated completion | 10 October 2025 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- control group — full drug profile →
- experimental group
- EEG power in alpha band
Conditions studied
- Dystonia — all drugs for Dystonia →
- Neurologic Disorder — all drugs for Neurologic Disorder →
- NEUROSCIENCE — all drugs for NEUROSCIENCE →
Sponsor
IRCCS Centro Neurolesi Bonino Pulejo — full company profile →
Who can join
Adults 18 to 60, any sex, with Dystonia or Neurologic Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Dystonias represent hyperkinetic movement disorders characterized by protracted muscle contractions, such as to cause torsional movements and anomalous postures in different parts of the body. Although they occur more often in a focal form (blepharospasm, oromandibular dystonia, cervical dystonia, laryngeal dystonia, attitudinal cramps of the limbs) than segmental (involvement of several contiguous muscle groups, e.g. facial muscles and neck muscles), they are nevertheless capable of significantly influencing the quality of life, with consequent social and health costs. Although described as a predominantly motor disorder, the presence of non-motor symptoms in dystonias associated with alteration of the fronto-striatal circuits is increasingly recognized. Neuroimaging studies have highlighted that the striatum and, more specifically, striatal dopamine, is involved in high cognitive processes such as attention, reward-based learning and decision making. Clinical conditions associated with cortico-striatal circuit dysfunction and abnormal meso-striatal or meso-cortical dopamine transmission also appear to influence temporal estimation, delay discounting, showing an impulsive preference for immediate rewards over delayed gratification. Based on these premises, the present project aims to evaluate the cognitive and affective aspects of dystonias, in line with neuroimaging research documenting structural and functional dysfunctions in the respective brain regions.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06264063
- Europe PMC full search
- ASCO Meeting Library
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Other IRCCS Centro Neurolesi Bonino Pulejo trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06264063 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by IRCCS Centro Neurolesi Bonino Pulejo
- Last refreshed: 31 March 2026
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