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NCT06263595
Semaglutide and Preoperative Residual Gastric Volumes
trial testing gastric antral sonography in Pulmonary Aspiration in 94 participants. Completed in 16 May 2025.
31 July 2025
Quick facts
| Lead sponsor | University of Calgary |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 94 |
| Start date | 31 May 2024 |
| Primary completion | 31 July 2025 |
| Estimated completion | 16 May 2025 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- gastric antral sonography
Conditions studied
- Pulmonary Aspiration — all drugs for Pulmonary Aspiration →
Sponsor
University of Calgary
Who can join
18 and older, any sex, with Pulmonary Aspiration. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Given the pharmacodynamic and pharmacokinetic properties of glucagon-like peptide-1 (GLP-1) agonists, the Canadian Anesthesiologists' Society has recognized that patients on GLP-1 agonists may have an increased aspiration risk due to a 'full stomach,' even after following preoperative fasting guidelines. In other words, safe fasting timelines are not known in individuals taking GLP-1 agonists, as demonstrated by recent case reports of patients who either retained or regurgitated stomach contents despite being adequately fasted. To address this gap, we plan to measure preoperative residual gastric volumes with point-of-care ultrasound (POCUS) in patients taking this medication. The priority is to first gather data to identify which patient populations need risk stratification and to then use this data to support the development of specific guidelines that reduce anesthetic complications, such as aspiration pneumonia. Our primary objective is to use POCUS preoperatively to assess gastric volumes of fasted patients to demonstrate if there is a clinically significant increase in residual gastric volumes in patients on semaglutide.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
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Related trials
Other recruiting trials for Pulmonary Aspiration
Currently open trials in the same condition.
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Other University of Calgary trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06263595 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Calgary
- Last refreshed: 25 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06263595.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing