NCT06654219 is a NA clinical trial of GLP-1 RA users with prolonged fasting instructions in Pulmonary Aspiration, sponsored by The University of Texas Health Science Center, Houston.

Who is sponsoring NCT06654219?

NCT06654219 is sponsored by The University of Texas Health Science Center, Houston.

What drugs are being tested in NCT06654219?

Interventions in NCT06654219: GLP-1 RA users with prolonged fasting instructions, GLP-1 RA users with standard NPO instructions.

What condition does NCT06654219 study?

NCT06654219 studies Pulmonary Aspiration.

Is NCT06654219 still recruiting?

NCT06654219 is currently recruiting now. Last updated 3 November 2025.

Last reviewed 2025-11-03 · How we verify

NCT06654219

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Protective Benefits of a Clear Liquid Diet on Residual Gastric Content in Patients Taking Glucagon Like Peptide-1 Receptor (GLP-1 RA) Agonist Prior to Anesthesia

Recruiting now NA Last updated 3 November 2025

What this trial tests

NA trial testing GLP-1 RA users with prolonged fasting instructions in Pulmonary Aspiration in 136 participants. Currently enrolling.

Timeline

30 October 2025

Primary endpoint
1 May 2026

1 May 2026

Quick facts

Lead sponsor	The University of Texas Health Science Center, Houston
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	136
Start date	30 October 2025
Primary completion	1 May 2026
Estimated completion	1 May 2026
Sites	1 location across United States

Drugs / interventions tested

GLP-1 RA users with prolonged fasting instructions
GLP-1 RA users with standard NPO instructions

Conditions studied

Pulmonary Aspiration — all drugs for Pulmonary Aspiration →

Sponsor

The University of Texas Health Science Center, Houston

Who can join

18 and older, any sex, with Pulmonary Aspiration. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to determine if prolonged fasting from solids and transitioning to a CLD for 24 hours is protective to decrease RGC in patients on GLP-1 RAs presenting for upper endoscopy, to determine if prolonged fasting is associated with increased thirst, hunger and anxiety, To determine if signs and symptoms of nausea, vomiting, retching, abdominal bloating, and abdominal pain are present on the day of surgery, to see if there is any variability between preoperative gastric ultrasound assessment and volume of gastric contents visualized on upper endoscopy, to determine time of gastric emptying by serial Gastric ultrasonography (GUS) scans every 2 hours in subjects who presented with an initial at-risk scan, to determine the choice of anesthesia used based on preoperative GUS results, to determine if there were any adverse events recorded in this study group, to determine if duration of GLP-1 RA therapy has an association with residual gastric content (RGC). and to determine if dosing of GLP-1 RA has an association with RGC.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Association between glucagon-like peptide-1 receptor agonist use and peri-operative pulmonary aspiration: a systematic review and meta-analysis.
Elkin J, Rele S, Sumithran P, Hii M, et al · · 2025 · cited 12× · PMID 40230298 · DOI 10.1111/anae.16601
New therapeutic agents for type 2 diabetes: anaesthetic considerations. A narrative review.
Doroba O, Czupryniak L, Sanfilippo F, Andruszkiewicz P, et al · · 2025 · PMID 40995652 · DOI 10.5114/ait/208895

Verify or expand the search:

Other recruiting trials for Pulmonary Aspiration

Currently open trials in the same condition.

NCT06621706 — Ultrasound Assessment of Gastric Volume in Diabetic Versus Non-Diabetic Term Pregnant Women Undergoing Cesarean Section · recruiting

Other The University of Texas Health Science Center, Houston trials

Trials by the same sponsor.

NCT04200729 — Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-cente · Phase 4 · not yet recruiting
NCT07225062 — Improving HIV Prevention and Substance Use Post-Sexual Assault Services · NA · not yet recruiting
NCT07396974 — Increasing Treatment Access in Trauma Exposed Children: Developing an Adapted Step One Intervention (RCT) · NA · not yet recruiting
NCT07170163 — Navigating the Transition to Adulthood: A Dual Language Mobile App for Latino Youth With ASD and Their Families · NA · not yet recruiting
NCT06915441 — Lipid Infusions to Optimize Nutrition Trial · Phase 2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06654219 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The University of Texas Health Science Center, Houston
Last refreshed: 3 November 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06654219.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing