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NCT06235320: PIS-PaB
Paracetamol Effect on Prostaglandins and Blood Pressure
trial testing routine clinical treatment of pain with paracetamol or ibuprofen in Pain in 72 participants. Not yet recruiting.
1 March 2026
Quick facts
| Lead sponsor | Charite University, Berlin, Germany |
|---|---|
| Status | Not yet recruiting |
| Study type | OBSERVATIONAL |
| Enrollment | 72 |
| Start date | 1 March 2025 |
| Primary completion | 1 March 2026 |
| Estimated completion | 1 September 2026 |
Drugs / interventions tested
- routine clinical treatment of pain with paracetamol or ibuprofen
Conditions studied
- Pain — all drugs for Pain →
Sponsor
Charite University, Berlin, Germany
Who can join
18 and older, any sex, with Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This research program aims to investigate the influence of paracetamol on blood pressure and the cyclooxygenase (COX) - prostaglandine (PG) pathway in patients with pain. Through an observational pilot study, we will use advanced LC/ESI-MS/MS methodology to analyze the COX-OG pathway in plasma and urine. The study will assess the effects of paracetamol compared to ibuprofen, considering different types of pain. The primary focus is to understand the changes in blood pressure and the COX-PG pathway upon initiation or discontinuation of paracetamol, with safety analysis as a secondary consideration.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06235320
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06235320 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Charite University, Berlin, Germany
- Last refreshed: 26 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06235320.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing