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NCT06204679
Pharmacokinetics of Fixed-Dose Combination Tablet of Bemnifosbuvir and Ruzasvir
Phase 1 trial testing Bemnifosbuvir (BEM)/Ruzasvir (RZR) FDC under fasting conditions in Healthy Volunteer Study in 42 participants. Completed in 25 August 2024.
25 August 2024
Quick facts
| Lead sponsor | Atea Pharmaceuticals, Inc. |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 42 |
| Start date | 14 December 2023 |
| Primary completion | 25 August 2024 |
| Estimated completion | 25 August 2024 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Bemnifosbuvir (BEM)/Ruzasvir (RZR) FDC under fasting conditions — full drug profile →
- Bemnifosbuvir (BEM)/Ruzasvir (RZR) FDC under fed conditions — full drug profile →
- Bemnifosbuvir (BEM) and Ruzasvir (RZR) as reference formulation under fasting conditions — full drug profile →
Conditions studied
- Healthy Volunteer Study — all drugs for Healthy Volunteer Study →
Sponsor
Atea Pharmaceuticals, Inc. — full company profile →
Who can join
Adults 18 to 65, any sex, with Healthy Volunteer Study. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will assess comparative bioavailability and effect of food on a prototype fixed-dose combination (FDC) of Bemnifosbuvir (BEM) and Ruzasvir (RZR) in healthy subjects
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Clinical Evaluation of Potential Interaction Between Bemnifosbuvir and Ruzasvir With an Assessment of Food Effect: Results of a Phase 1 Study in Healthy Participants.
Zhou XJ, Morelli G, Montrond M, Lynch S, et al · · 2025 · cited 2× · PMID 40272375 · DOI 10.1002/cpdd.1540
Verify or expand the search:
- PubMed search for NCT06204679
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Atea Pharmaceuticals, Inc. trials
Trials by the same sponsor.
- NCT07272889 — Drug-drug Interaction Study of Bemnifosbuvir/Ruzasvir (BEM/RZR) and Ethinyl Estradiol/Levonorgestrel (EE/LNG) · Phase 1 · completed
- NCT07007806 — Drug-drug Interaction Study of Omeprazole and Bemnifosbuvir/Ruzasvir · Phase 1 · completed
- NCT06921941 — Drug-drug Interaction Study of Bemnifosbuvir/Ruzasvir (BEM/RZR) and Digoxin and Rosuvastatin · Phase 1 · completed
- NCT06356194 — Drug-drug Interaction Study of Biktarvy and Bemnifosbuvir/Ruzasvir · Phase 1 · completed
- NCT05904470 — A Phase 2, Safety and Efficacy of Bemnifosbuvir (BEM) and Ruzasvir (RZR) in Subjects With Chronic HCV · Phase 2 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06204679 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Atea Pharmaceuticals, Inc.
- Last refreshed: 19 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06204679.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing