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NCT06194721
The Effect of Intra-pulpal Anesthesia With Cryotherapy on Intra-operative Pain
NA trial testing Cold intrapulpal anesthesia in Irreversible Pulpitis in 40 participants. Completed in 6 January 2025.
6 December 2024
Quick facts
| Lead sponsor | Gulf Medical University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 40 |
| Start date | 6 June 2023 |
| Primary completion | 6 December 2024 |
| Estimated completion | 6 January 2025 |
| Sites | 1 location across United Arab Emirates |
Drugs / interventions tested
- Cold intrapulpal anesthesia
- Room temperature intrapulpal anesthesia
Conditions studied
- Irreversible Pulpitis — all drugs for Irreversible Pulpitis →
Sponsor
Gulf Medical University
Who can join
Adults 18 to 70, any sex, with Irreversible Pulpitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to compare the effect of cooling of local anesthesia on intraoperative pain during root canal treatment in mandibular molars diagnosed as symptomatic irreversible pulpitis. The main question it aims to answer is: Is there a difference in intra-operative pain levels using intra-pulpal anesthesia with and without cryotherapy during root canal treatment? Participants will undergo root canal treatment using intrapulpal anesthesia with and without cooling. Researchers will compare cold and room temperature intrapulpal anesthesia to see the intensity of intraoperative pain.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effect of intrapulpal cryoanesthesia on intraoperative pain during root canal treatment in mandibular molars: a double blinded randomized control trial.
Eldafrawi S, Elsewify T, Elemam R, Eid B. · · 2025 · PMID 41136539 · DOI 10.1038/s41598-025-21173-5
Verify or expand the search:
- PubMed search for NCT06194721
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Irreversible Pulpitis
Currently open trials in the same condition.
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- NCT06730360 — Clinical and Radiographic Assessment of Photobiomodulated MTA Pulpotomy in Immature First Permanent Molars with Irrevers · NA · recruiting
Other Gulf Medical University trials
Trials by the same sponsor.
- NCT07468747 — Influence of Implant Insertion Depth on Peri-implant Bone Changes Around Short Implants · NA · not yet recruiting
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- NCT07468773 — Effect of Individually Trained Oral Prophylaxis (iTOP) on Gingival Health in Orthodontic Patients · NA · not yet recruiting
- NCT07196826 — Effect of Passive Versus Active Aquatic Therapy Compared With Conventional Physiotherapy for Chronic Low Back Pain · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06194721 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Gulf Medical University
- Last refreshed: 18 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06194721.
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