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NCT06193161
Prolonged Exposure for Swedish Immigrants
NA trial testing Therapist-supported internet delivered prolonged exposure in Posttraumatic Stress Disorder in 100 participants. Currently enrolling.
15 October 2025
Quick facts
| Lead sponsor | Karolinska Institutet |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 15 March 2024 |
| Primary completion | 15 October 2025 |
| Estimated completion | 15 March 2026 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Therapist-supported internet delivered prolonged exposure
Conditions studied
- Posttraumatic Stress Disorder — all drugs for Posttraumatic Stress Disorder →
Sponsor
Karolinska Institutet
Who can join
18 and older, any sex, with Posttraumatic Stress Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to compare therapist-guided internet delivered prolonged exposure (I-PE) in simple english to a waiting list condition for immigrants in Sweden diagnosed with post-traumatic stress disorder (PTSD). The main objectives are to establish feasibility and preliminary efficacy of I-PE for immigrants with PTSD in a single-blind, parallel-group superiority Randomized Controlled Trial (N=100) comparing I-PE with a waiting-list condition, starting with a nested pilot (N=30) to ensure feasible and acceptable recruitment and treatment strategies. Study participants will be randomly assigned to either eight weeks of I-PE or a waiting-list for the same amount of time on a 1:1 ratio without restriction. Feasibility and acceptability data will be reported including recruitment rate, sample demographics, data attrition, treatment adherence and a detailed dropout analysis. A preliminary investigation of the within-group effect size will also be conducted. Recruitment is designed to be broadly inclusive with minimal exclusion criteria.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Mind the Gap: scaling-up access to culturally adapted mental health treatments for minority populations.
Molander O, Särnholm J, Hollander AC, Jayaram-Lindström N. · · 2024 · cited 3× · PMID 39681953 · DOI 10.1186/s44263-024-00092-z -
Mind the gap: a nested randomised pilot study of culturally inclusive, internet-delivered prolonged exposure for PTSD among immigrants.
Molander O, Kolaas K, Jayaram-Lindström N, Pontén M, et al · · 2025 · PMID 40587567 · DOI 10.1080/20008066.2025.2520637
Verify or expand the search:
- PubMed search for NCT06193161
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06193161 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Karolinska Institutet
- Last refreshed: 9 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06193161.
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