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NCT06190015
Impact of Advanced Platelet Rich Fibrin and Enamel Matrix Derivative on Clinical and Molecular Wound Healing Parameters After Surgical Removal of Mandibular Third Molars
Phase 4 trial testing Advanced platelet rich fibrin (APRF) clots in Surgical Wound, Healed in 120 participants. Status unknown.
20 January 2024
Quick facts
| Lead sponsor | University of Belgrade |
|---|---|
| Phase | Phase 4 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 120 |
| Start date | 23 May 2022 |
| Primary completion | 20 January 2024 |
| Estimated completion | 20 March 2024 |
| Sites | 1 location across Serbia |
Drugs / interventions tested
- Advanced platelet rich fibrin (APRF) clots — full drug profile →
- Enamel matrix derivative (EMD) group
Conditions studied
- Surgical Wound, Healed — all drugs for Surgical Wound, Healed →
- Post Operative Pain — all drugs for Post Operative Pain →
Sponsor
University of Belgrade
Who can join
Adults 18 to 30, any sex, with Surgical Wound, Healed or Post Operative Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Brief summary The goal of this study is to compare the effects of advanced platelet rich fibrin and enamel matrix derivative placed in the extraction alveoli of patients who had surgical removal of mandibular wisdom teeth. The questions it aims to answer/evaluate are: * postoperative pain, swelling, trismus, early wound healing using soft tissue healing index * level of early local inflammatory response by measuring levels of inflammatory mediators in wound exudate * degree of wound healing by measuring levels of early wound healing mediators in wound exudate * incidence of alveolar osteitis and delayed infection * levels of probing depth, clinical attachment loss, gingival margin level, bleeding on probing, gingival index, plaque index of the second mandibular molar 3 months after surgery Participants of the study will be asked: * for their preoperative clinical measurements (swelling, trismus, periodontal parameters) to be taken by the principal investigator * to provide 20 ml of venous blood if necessary * to preoperatively provide gingival crevicular fluid in the region of distal surface of the second mandibular molar and postoperatively wound exudate * to note the number of painkiller pills taken after surgery and pain levels in different time points * to come to regular checkups in which clinical measuring of postoperative swelling, trismus levels and periodontal parameters will be performed
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06190015
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Related trials
Other recruiting trials for Surgical Wound, Healed
Currently open trials in the same condition.
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Other University of Belgrade trials
Trials by the same sponsor.
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- NCT06885983 — Healing After Augmentation of Alveolar Ridge Using Collagen Membrane · NA · enrolling by invitation
- NCT07378709 — Exploratory Blood-Based Biomarkers in TACE-Treated Hepatocellular Carcinoma · recruiting
- NCT06349382 — CArbohydrate Loading in Aortic Surgery · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06190015 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Belgrade
- Last refreshed: 5 January 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06190015.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing