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NCT06169917
Pain Processing In Relation To Breathing
NA trial testing Paced Resonance Frequency Breathing in Central Sensitisation in 200 participants. Status unknown.
31 May 2025
Quick facts
| Lead sponsor | Balgrist University Hospital |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 200 |
| Start date | 14 May 2023 |
| Primary completion | 31 May 2025 |
| Estimated completion | 31 May 2025 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Paced Resonance Frequency Breathing
- Paced Breathing at Natural Frequency
- Heat Stimulations
Conditions studied
- Central Sensitisation — all drugs for Central Sensitisation →
- Pain — all drugs for Pain →
Sponsor
Balgrist University Hospital
Who can join
Adults 18 to 40, any sex, with Central Sensitisation or Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to investigate the effect of breathing on the processing of experimental pain in healthy participants. The main questions are: 1. Does breathing rate influence the spatial extent of thermally induced secondary hyperalgesia, a proxy of central sensitization? 2. Does resonance frequency breathing influence the autonomic nervous system, compared to baseline and compared to paced breathing at a natural frequency? 3. Is spinal excitability, measured using the magnitude of the nociception withdrawal reflex (NWR), affected by resonance frequency breathing, compared to paced breathing at a natural frequency? Participants: * will receive heat stimuli * 's skin's sensitivity will be tested using quantitative sensory testing tools. * will receive various instructions on the speed of their breathing * 's heart rate, respiratory rate and sweat response will be measured * will fill in questionnaires Researchers will compare the spatial extent of sensitivity resulting from application of heat stimuli during paced resonance frequency breathing compared to paced breathing at a natural frequency to see if the breathing rhythm influences central sensitization processes.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06169917
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Other Balgrist University Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06169917 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Balgrist University Hospital
- Last refreshed: 14 December 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06169917.
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