Last reviewed · How we verify
NCT06152718: Karisma
New Regenerative Approach for Dermal Renovation (Karisma)
NA trial testing Karisma in Skin Manifestations in 100 participants. Completed in 30 December 2024.
30 June 2024
Quick facts
| Lead sponsor | University of Palermo |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 1 December 2023 |
| Primary completion | 30 June 2024 |
| Estimated completion | 30 December 2024 |
| Sites | 2 locations across Serbia, Italy |
Drugs / interventions tested
- Karisma
Conditions studied
- Skin Manifestations — all drugs for Skin Manifestations →
Sponsor
University of Palermo
Who can join
Adults 20 to 65, any sex, with Skin Manifestations. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Purpose/Objectives of the Study: Regenerative medicine, as well as aesthetic plastic surgery and dermatology field persistently seeks innovative, minimally invasive interventions to enhance skin quality and mitigate signs of aging. This study evaluates the regenerative capabilities of a new medical device focused on dermal redensification, induced by injections of single-strand alpha 1 collagen, to verify its ability, in a specific formulation (contained within a matrix of hyaluronic acid and carboxymethylcellulose), to induce dermal stimulation in both scar outcomes and regenerative medicine applied to skin aging.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
New Regenerative and Anti-Aging Medicine Approach Based on Single-Stranded Alpha-1 Collagen for Neo-Collagenesis Induction: Clinical and Instrumental Experience of a New Injective Polycomponent Formulation for Dermal Regeneration.
Di Rosa L, De Pasquale A, Baldassano S, Marguglio N, et al · · 2024 · cited 3× · PMID 38672270 · DOI 10.3390/biomedicines12040916
Verify or expand the search:
- PubMed search for NCT06152718
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Skin Manifestations
Currently open trials in the same condition.
- NCT05987163 — Study to Evaluate the Safety and Effectiveness of GP0116 · NA · active not recruiting
Other University of Palermo trials
Trials by the same sponsor.
- NCT03017716 — Inflammatory Back Pain and Gluten Free Diet · NA · not yet recruiting
- NCT07364149 — Acute Effects of Structured Exercise and Static Stretching on Vascular Function, Neuromuscular Performance, and Metaboli · NA · recruiting
- NCT06206616 — Liver Steatosis in Pediatric CD Patients · not yet recruiting
- NCT07433543 — Foam Rolling, Blood Pressure and Range of Motion · NA · completed
- NCT07213011 — Effects of Static Stretching and Self-myofascial Release on Local and Remote Range of Motion · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06152718 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Palermo
- Last refreshed: 12 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06152718.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing