NCT06139432: CATATOES

Catatonia: Effectiveness of Transcranial Direct Current Electrostimulation (CATATOES)

Status unknown NA Last updated 24 November 2023

What this trial tests

NA trial testing Active tDCS in Catatonia in 70 participants. Status unknown.

Timeline

1 December 2023

Primary endpoint
31 December 2025

31 December 2025

Quick facts

Lead sponsor	Centre Hospitalier St Anne
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	70
Start date	1 December 2023
Primary completion	31 December 2025
Estimated completion	31 December 2025
Sites	2 locations across France

Drugs / interventions tested

• Active tDCS
• Sham tDCS

Conditions studied

• Catatonia — all drugs for Catatonia →

Sponsor

Centre Hospitalier St Anne

Who can join

18 and older, any sex, with Catatonia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Nearly 10% of people hospitalized in psychiatry have a catatonic syndrome. The treatment of this syndrome is based on lorazepam and electro-convulsive therapy (ECT) in drug-resistant forms. ECT is the reference therapy, very effective in catatonia, but remain difficult to access due to the technical platform required for their realization, leading to delays in the implementation of the treatment responsible for an increase in the morbidity and mortality of catatonia. In this context, a new therapeutic tool available in the treatment of drug-resistant catatonia would improve the prognosis of catatonia. Transcranial direct current stimulation (tDCS) is an alternative, non-invasive brain stimulation technique that does not require anesthesia, and inexpensive and has been shown to be effective in depression and schizophrenia. A series of clinical cases suggests its potential efficacy in catatonia. Our objective is to evaluate the efficacy of tDCS in catatonia in a clinical trial.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Moving to accelerated protocols of tDCS in catatonia: a case report.
   Bouaziz N, Luisada JC, Jabri S, Andrianisaina PS, et al · · 2023 · cited 6× · PMID 38188043 · DOI 10.3389/fpsyt.2023.1302718
2. CATATOnia treatment with transcranial direct current electrostimulation: protocol of a randomised, double-blind, placebo-controlled bicentric superiority study (CATATOES).
   Moyal M, Attali D, Berre AL, Bouaziz N, et al · · 2025 · PMID 41062970 · DOI 10.1186/s12888-025-07266-5
3. CATATOnia treatment with transcranial direct current ElectroStimulation: protocol of a randomised, double-blind, placebo-controlled bicentric superiority study (CATATOES)
   Moyal M, Attali D, Berre AL, Bouaziz N, et al · · 2024 · DOI 10.21203/rs.3.rs-5355181/v1