NCT06127693 (CAIR) is a clinical trial of Tetravalent Influenza Vaccine in Chronic Pain, sponsored by University of Cape Town.

Who is sponsoring NCT06127693?

NCT06127693 is sponsored by University of Cape Town.

What drugs are being tested in NCT06127693?

Interventions in NCT06127693: Tetravalent Influenza Vaccine, High-frequency electrical stimulation.

What condition does NCT06127693 study?

NCT06127693 studies Chronic Pain, Central Sensitisation, Immune Response, Adverse Childhood Experiences.

Is NCT06127693 still recruiting?

NCT06127693 is currently completed. Last updated 13 November 2023.

Last reviewed 2023-11-13 · How we verify

NCT06127693: CAIR

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Childhood Adversity, Inflammatory Reactivity and Persistent Pain

Completed Last updated 13 November 2023

What this trial tests

trial testing Tetravalent Influenza Vaccine in Chronic Pain in 101 participants. Completed in 20 September 2023.

Timeline

21 June 2022

Primary endpoint
20 September 2023

20 September 2023

Quick facts

Lead sponsor	University of Cape Town
Status	Completed
Study type	OBSERVATIONAL
Enrollment	101
Start date	21 June 2022
Primary completion	20 September 2023
Estimated completion	20 September 2023
Sites	1 location across South Africa

Drugs / interventions tested

Tetravalent Influenza Vaccine — full drug profile →
High-frequency electrical stimulation

Conditions studied

Chronic Pain — all drugs for Chronic Pain →
Central Sensitisation — all drugs for Central Sensitisation →
Immune Response — all drugs for Immune Response →
Adverse Childhood Experiences — all drugs for Adverse Childhood Experiences →

Sponsor

University of Cape Town

Who can join

Adults 18 to 65, any sex, with Chronic Pain or Central Sensitisation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this observational study is to investigate how adverse experiences during childhood are linked to people experiencing persistent pain and fatigue in adulthood. The questions the investigators aim to answer are: 1. Does participant-reported childhood adversity predict levels of IL-6 and TNF-α after in vitro provocation of whole blood using endotoxin? 2. Do levels of IL-6 and TNF-α after in vitro immune provocation using endotoxin predict vulnerability to persistent pain and fatigue after in vivo immune provocation (tetravalent influenza vaccine)? 3. Do levels of IL-6 and TNF-α after in vitro immune provocation using endotoxin predict vulnerability to persistent pain and fatigue after in vivo neural provocation? For this study, the investigators will recruit and enrol 96 healthy human adults (18 - 65 years old) with a range of adverse experiences during childhood. Participants will attend 2 study sessions during which the investigators will take a sample of blood, assess pressure pain threshold before and after cold water immersion, assess heart rate variability, and assess the surface area of secondary skin hypersensitivity after electrical stimulation. At the end of the first session, participants will receive the influenza vaccination.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Inflammatory reactivity is unrelated to childhood adversity or provoked modulation of nociception.
Bedwell GJ, Mqadi L, Kamerman P, Hutchinson MR, et al · · 2025 · cited 3× · PMID 40372281 · DOI 10.1097/j.pain.0000000000003658

Verify or expand the search:

Other recruiting trials for Chronic Pain

Currently open trials in the same condition.

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NCT07270406 — Healthy Behaviors for Insomnia Prevention in People With HIV and Ongoing Pain · NA · recruiting

Other University of Cape Town trials

Trials by the same sponsor.

NCT06997328 — '5 Rs to Rescue' A Cluster Trial With an Embedded Process Evaluation · recruiting
NCT06431321 — Evaluation of a 2-session Parent Training Programme for Caregivers of Younger Children in Zimbabwe · NA · not yet recruiting
NCT06051526 — The African Critical Illness Outcomes Study · completed
NCT05723484 — Comparing a Novel Point-of-care Cytokine Biomarker Lateral Flow Test With Nucleic Acid Amplification Tests for Detection · completed
NCT05681871 — South African Paediatric Surgical Outcomes Study 2 · Phase 4 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06127693 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Cape Town
Last refreshed: 13 November 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06127693.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing