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NCT06113276: CT4ARDS-2
Quantitative Computed Tomography for Mortality Risk Stratification in ARDS
trial testing Low dose computed tomography to evaluate biomechanical parameters in the lung in Acute Respiratory Distress Syndrome in 210 participants. Status unknown.
1 November 2024
Quick facts
| Lead sponsor | Hospices Civils de Lyon |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 210 |
| Start date | 6 November 2020 |
| Primary completion | 1 November 2024 |
| Estimated completion | 1 May 2025 |
| Sites | 4 locations across France |
Drugs / interventions tested
- Low dose computed tomography to evaluate biomechanical parameters in the lung
Conditions studied
- Acute Respiratory Distress Syndrome — all drugs for Acute Respiratory Distress Syndrome →
Sponsor
Hospices Civils de Lyon — full company profile →
Who can join
15 and older, any sex, with Acute Respiratory Distress Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Acute respiratory distress syndrome remains a deadly disease with hospital mortality remaining between 40 to 50%. ARDS mortality risk factors have been identified from patient history, common clinical and biological variables in the lung SAFE study. Part of ARDS mortality is attributable to ventilator-induced lung injury (VILI), in relation with inappropriate settings on the ventilator. Tidal hyperinflation and recruitment/derecruitment during lung inflation are 2 identified mechanisms leading to VILI, that may be identified on computed tomography while poorly identified with variables collected at the bedside. The aim of this study is to identify whether tidal hyperinflation identified on computed tomography is a risk factor for ARDS mortality, independently from know bio-clinical risk factors.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Prognostic value of functional CT imaging in COVID-ARDS: a two-centre prospective observational study.
Shekarnabi M, Guillien A, Terzi N, Sigaud F, et al · · 2025 · cited 2× · PMID 40346553 · DOI 10.1186/s12931-025-03232-7 -
Physiological and clinical effects of two ultraprotective ventilation strategies in patients with veno-venous extracorporeal membrane oxygenation: the ECMOVENT study.
Rodriguez Y, Thomachot A, Deniel G, Mezidi M, et al · · 2025 · PMID 40748578 · DOI 10.1186/s13613-025-01525-0 -
Diagnostic performance of the recruitment-to-inflation ratio to assess lung recruitability by PEEP in ARDS. a computed tomography study.
Richard JC, Dhelft F, Deniel G, Roux E, et al · · 2025 · PMID 40462166 · DOI 10.1186/s13054-025-05453-0
Verify or expand the search:
- PubMed search for NCT06113276
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acute Respiratory Distress Syndrome
Currently open trials in the same condition.
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- NCT07289711 — Validation and Precision Treatment of Inflammatory Subphenotypes in Acute Respiratory Distress Syndrome: A Multicenter C · recruiting
- NCT07326215 — A Study of the Efficacy and Safety of Extracorporeal Carbon Dioxide Removal Using PrismaLung+ · NA · recruiting
- NCT06919484 — The Physiological Effect of RCexp on Ventilation/Perfusion Distribution · recruiting
- NCT07126964 — Extended Prone Positioning for Intubated ARDS · NA · recruiting
Other Hospices Civils de Lyon trials
Trials by the same sponsor.
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- NCT07474532 — Attitudes and Beliefs Related to Benzodiazepine Deprescribing · not yet recruiting
- NCT07313007 — Assessment of Gut Microbiota-Derived Amino Acid Metabolite Production in Patients With MASLD · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06113276 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospices Civils de Lyon
- Last refreshed: 31 January 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06113276.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing