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NCT06106386
The Effect of Different Intraradicular Cryotherapy on Post-operative Pain and the Level of Substance P
NA trial testing cryotherapy in Post Operative Pain in 135 participants. Completed in 1 March 2024.
1 February 2024
Quick facts
| Lead sponsor | Ain Shams University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 135 |
| Start date | 1 January 2024 |
| Primary completion | 1 February 2024 |
| Estimated completion | 1 March 2024 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- cryotherapy (CRYOTHERAPY) — full drug profile →
Conditions studied
- Post Operative Pain — all drugs for Post Operative Pain →
- Inflammation — all drugs for Inflammation →
Sponsor
Ain Shams University
Who can join
Adults 18 to 40, any sex, with Post Operative Pain or Inflammation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this clinical trial is to evaluate the effect of using intra-radicular cryotherapy technique in the form of irrigation with cold sodium hypochlorite The main questions to answer are: 1. Does Postoperative pain is different between the three groups? 2. Does level of substance P different between the three groups ?
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The impact of using cold irrigation on postoperative endodontic pain and substance P level: a randomized clinical trial.
Sharaf RMA, Abdelrahman TY, Obeid MF. · · 2026 · cited 1× · PMID 40533695 · DOI 10.1007/s10266-025-01131-3
Verify or expand the search:
- PubMed search for NCT06106386
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT04571307 — Cryotherapy in Breast B3 Lesions · NA · unknown
- NCT04760873 — Cryotherapy for GAVE · NA · withdrawn
- NCT04558034 — The Use of Cryotherapy to Prevent Paclitaxel-induced Peripheral Neuropathy and Nail Changes in Women With Breast Cancer · NA · terminated
Other recruiting trials for Post Operative Pain
Currently open trials in the same condition.
- NCT06779604 — Dexmedetomidine and Dexamethasone Added as Adjuvant Infraclavicular Brachial Plexus Block in Upper Limb Surgery · recruiting
- NCT07223580 — A Study Of Corticosteroid On Postoperative Pain After Ureteroscopy For Urinary Calculi · Phase 4 · recruiting
- NCT07227064 — Methadone in THA for Post-op Pain and Opioid Reduction · Phase 3 · recruiting
- NCT07226076 — Methadone in TKA for Post-op Pain and Opioid Reduction · Phase 3 · recruiting
- NCT07349810 — Post Operative Infusion Pump Pain Study · Phase 4 · recruiting
Other Ain Shams University trials
Trials by the same sponsor.
- NCT07435493 — Fentanyl Versus Opioid Free Multimodal Analgesia for Perioperative Pain Control in Children With Mild to Moderate Obstru · NA · not yet recruiting
- NCT07482540 — Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery · NA · not yet recruiting
- NCT07531030 — Posterior Pericapsular Deep Gluteal Block Combined With Pericapsular Nerve Group and Lateral Femoral Cutaneous Nerve Blo · NA · not yet recruiting
- NCT06839027 — Arterial to Central co2gap in Relation to Outcome After Cardiopulmonary Bypass · not yet recruiting
- NCT07516535 — DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06106386 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ain Shams University
- Last refreshed: 13 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06106386.
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