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NCT06104280: MOUD
Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment
trial testing Post-Illumination Pupillary Response (PIPR) in Opioid Use Disorder in 200 participants. Currently enrolling.
28 December 2028
Quick facts
| Lead sponsor | University of Alabama at Birmingham |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 200 |
| Start date | 6 January 2025 |
| Primary completion | 28 December 2028 |
| Estimated completion | 1 January 2029 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- Post-Illumination Pupillary Response (PIPR)
- Polysomnography
- Multiple Sleep Latency Test
- Ecological Momentary Assessments
- Actigraphy
- DLMO
- Melatonin Suppression Test
Conditions studied
- Opioid Use Disorder — all drugs for Opioid Use Disorder →
- Sleep Disturbance — all drugs for Sleep Disturbance →
Sponsor
University of Alabama at Birmingham
Who can join
Adults 18 to 80, any sex, with Opioid Use Disorder or Sleep Disturbance. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Opioid use disorder (OUD) is a treatable medical illness with three medications FDA approved for treatment. However, persons with OUD report significant sleep disturbance, even when treated with medications for opioid use disorder, leading to high rates of relapse. In this project, we will investigate a special set of photosensitive neurons in the retina as an underlying mechanism for circadian rhythm and sleep disturbance from opioid use and medications for OUD that could lead to novel intervention and improve treatment outcomes.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06104280
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other University of Alabama at Birmingham trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06104280 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Alabama at Birmingham
- Last refreshed: 9 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06104280.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing