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NCT06088355: HI-LITE
Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease
NA trial testing HV-PDAE: High Volume Partnered Dance Aerobic Exercise in Parkinson Disease in 123 participants. Currently enrolling.
29 January 2028
Quick facts
| Lead sponsor | VA Office of Research and Development |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 123 |
| Start date | 25 January 2025 |
| Primary completion | 29 January 2028 |
| Estimated completion | 2 June 2029 |
| Sites | 1 location across United States |
Drugs / interventions tested
- HV-PDAE: High Volume Partnered Dance Aerobic Exercise
- MV-PDAE: Moderate Volume Partnered Dance Aerobic Exercise
- MV-WALK: Moderate Volume Walking
Conditions studied
- Parkinson Disease — all drugs for Parkinson Disease →
- Movement Disorders — all drugs for Movement Disorders →
- Neurodegeneration — all drugs for Neurodegeneration →
Sponsor
VA Office of Research and Development — full company profile →
Who can join
40 and older, any sex, with Parkinson Disease or Movement Disorders. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Veterans with mid to later stage Parkinson's disease (PD) may not be able to work out as hard as they need to, to prevent brain cell loss. Maybe they could work out longer and more frequently to make up for this during their good times and good weeks and then rest during the bad weeks. The investigators will compare how effective working out a lot one week per month with a break of three weeks is to continuously exercising weekly with no breaks in people with mid stage PD. The investigators will look at how fast participants walk per minute, whether they become more physically active, the biochemicals in their blood, and at how stiff their blood vessels are before and after the exercise.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06088355
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other VA Office of Research and Development trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06088355 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by VA Office of Research and Development
- Last refreshed: 5 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06088355.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing