Who is sponsoring NCT06078072?

NCT06078072 is sponsored by University Medical Centre Ljubljana.

What drugs are being tested in NCT06078072?

Interventions in NCT06078072: Biomaterials augmented with mesenchymal stem/stromal cells.

What condition does NCT06078072 study?

NCT06078072 studies Knee Injuries, Cartilage Injury, Osteochondral Defect.

Is NCT06078072 still recruiting?

NCT06078072 is currently completed. Last updated 30 November 2023.

Last reviewed 2023-11-30 · How we verify

NCT06078072

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Biomaterials and Mesenchymal Stem/Stromal Cells in the Treatment of Knee Articular Surface Lesions

Completed Last updated 30 November 2023

What this trial tests

trial testing Biomaterials augmented with mesenchymal stem/stromal cells in Knee Injuries in 90 participants. Completed in 31 October 2023.

Timeline

1 September 2022

Primary endpoint
31 August 2023

31 October 2023

Quick facts

Lead sponsor	University Medical Centre Ljubljana
Status	Completed
Study type	OBSERVATIONAL
Enrollment	90
Start date	1 September 2022
Primary completion	31 August 2023
Estimated completion	31 October 2023
Sites	1 location across Slovenia

Drugs / interventions tested

Biomaterials augmented with mesenchymal stem/stromal cells

Conditions studied

Knee Injuries — all drugs for Knee Injuries →
Cartilage Injury — all drugs for Cartilage Injury →
Osteochondral Defect — all drugs for Osteochondral Defect →

Sponsor

University Medical Centre Ljubljana

Who can join

Adults 18 to 65, any sex, with Knee Injuries or Cartilage Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this observational study is to evaluate the combined single-step approach with biomaterials and mesenchymal stem/stromal cells in the treatment of knee articular surface lesions. The clinical analysis of the treatment outcomes, regarding postoperative improvements and safety, is going to be accompanied with laboratory analysis of the intraoperatively applied cellular products. The main hypothesis are: (1) such combined single-step procedure significantly improves patients' functioning and quality of life; (2) this therapeutic approach is safe; (3) cellular parameters of the applied filtered bone marrow aspirate (fBMA) impact treatment outcomes, among other potential predictors. Researchers will compare subjective (questionnaire) and objective (clinical examination) status of patients before and after the operation, record any potential complications and perform regression analysis to assess the influence of potential predictors on postoperative improvements.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

A Biomimetic Osteochondral Scaffold Augmented With Filtered Bone Marrow Aspirate for the Treatment of Joint Surface Lesions in the Knee.
Kolar M, Veber M, Girandon L, Drobnič M. · · 2024 · cited 2× · PMID 38767159 · DOI 10.1177/03635465241247788
An overview of stem cells and cell products involved in trauma injury.
Saeedi P, Nilchiani LS, Zand B, Hajimirghasemi M, et al · · 2025 · cited 1× · PMID 40143930 · DOI 10.1016/j.reth.2025.02.011
Avenanthramide C and chondroitin sulphate promote chondrogenic differentiation of adipose-derived mesenchymal stem cells.
Sun P, Lim W, Talchai SC, Khemarangsan V. · · 2026 · PMID 41813772 · DOI 10.1038/s41598-026-42579-9

Verify or expand the search:

Other recruiting trials for Knee Injuries

Currently open trials in the same condition.

NCT07300098 — Epidemiological Evaluation of Knee Injuries in Children Admitted to Assiut University Hospitals From 2022 to 2025. · active not recruiting
NCT07201597 — Correlation Between Psychological Readiness, Knee Function, and Isokinetic Performance After Anterior Cruciate Ligament · recruiting
NCT06541756 — Fibrine Clot-augmented Repair of Longitudinal Meniscus Tears · NA · recruiting
NCT06442319 — The Efficiency and Safety of PRP Treatment After Anterior Cruciate Ligament Reconstruction. · NA · recruiting
NCT06195423 — Stopping OsteoARthritis After an ACL Tear · NA · recruiting

Other University Medical Centre Ljubljana trials

Trials by the same sponsor.

NCT07466472 — Image-Guided Central Catheter Insertion With Concurrent Assessment of Vascular Wall Integrity · not yet recruiting
NCT07446244 — Catheter Ablation of Advanced Forms of Atrial Fibrillation · NA · enrolling by invitation
NCT07109076 — Effect of Immediate Skin-to-Skin Contact on Neonatal Heart Rate Variability After Cesarean Secton · NA · recruiting
NCT07354880 — Effect of Tirzepatide on Cardiovascular and Metabolic Parameters in Obese Adult Patients With Congenital Heart Disease · Phase 4 · not yet recruiting
NCT07496736 — Post-exposure Influenza Prophylaxis in a Hospital Setting · Phase 3 · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06078072 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Medical Centre Ljubljana
Last refreshed: 30 November 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06078072.

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