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NCT06073158
Molecular Signatures of Esophageal Atresia
NA trial testing Esophageal biopsy collection during anastomosis in Esophageal Atresia in 6 participants. Completed in 4 March 2024.
4 March 2024
Quick facts
| Lead sponsor | University Hospital, Lille |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 6 |
| Start date | 1 September 2023 |
| Primary completion | 4 March 2024 |
| Estimated completion | 4 March 2024 |
| Sites | 1 location across France |
Drugs / interventions tested
- Esophageal biopsy collection during anastomosis
Conditions studied
- Esophageal Atresia — all drugs for Esophageal Atresia →
Sponsor
University Hospital, Lille
Who can join
Adults 1 Day to 1, any sex, with Esophageal Atresia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Although several studies have revealed signaling pathways as well as genes potentially involved in the development of esophageal atresia (EA), our understanding of the pathophysiology of EA lags behind improvements in the surgical and clinical care of patients born with this anomaly. However, a causative genetic abnormality can be identified in less than 10% of patients, even using more recent next-generation sequencing techniques. As most cases of EA associated with tracheoesophageal fistula (TOF) are sporadic, and the familial recurrence rate is low (1%), this suggests that epigenetic and environmental factors also contribute to the disease. Further investigations are needed to better understand the mechanisms underlying EA. That information can come from the oesophageal biopsies that are collected in routine care and long-term storage at the hospital. However, the impact of the length of the storage is still unknown.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06073158
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Esophageal Atresia
Currently open trials in the same condition.
- NCT06860919 — Prospective Evaluation of the Results of Multidisciplinary Follow-up After a Transitional Consultation for Esophageal At · recruiting
- NCT06975982 — Symptoms, Pulmonary Function, Muscle Strength, Exercise Capacity, and Frailty in Esophageal Atresia vs. Healthy Peers · recruiting
- NCT05995171 — Long Term Outcome of Easophageal Atresia : Transmics Profiles in Adolescence · recruiting
- NCT03730454 — Transanastomotic Tube for Proximal Esophageal Atresia With Distal Tracheoesophageal Fistula Repair · NA · active not recruiting
Other University Hospital, Lille trials
Trials by the same sponsor.
- NCT07528664 — Assessement of a Test a Financial-incentive Program for Pregnant Women and Their Smoking Partners to Reduce Smoking Duri · NA · not yet recruiting
- NCT07434739 — PAravertebral CaTheter Versus Epidural Analgesia in Totally Minimally Invasive Esophagectomies · NA · not yet recruiting
- NCT06958224 — Theranostic Approach by Early Multigene Sequencing in Advanced Poor Prognosis Cancers · NA · not yet recruiting
- NCT07408999 — Totally Versus Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer · NA · not yet recruiting
- NCT07492030 — Validation of the Use of the Arteriovenous Tension Difference in CO2 Under Hyperbaric Conditions · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06073158 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Lille
- Last refreshed: 26 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06073158.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing