Who is sponsoring NCT03730454?

NCT03730454 is sponsored by Phoenix Children's Hospital.

What drugs are being tested in NCT03730454?

Interventions in NCT03730454: Transanastomotic Tube (5FR), No Transanastomotic Tube.

What condition does NCT03730454 study?

NCT03730454 studies Esophageal Atresia, Tracheoesophageal Fistula.

Is NCT03730454 still recruiting?

NCT03730454 is currently active, enrolled. Last updated 10 March 2025.

Last reviewed 2025-03-10 · How we verify

NCT03730454: TEF

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Transanastomotic Tube for Proximal Esophageal Atresia With Distal Tracheoesophageal Fistula Repair

Active, enrolled NA Last updated 10 March 2025

What this trial tests

NA trial testing Transanastomotic Tube (5FR) in Esophageal Atresia in 142 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

11 May 2018

Primary endpoint
28 February 2025

28 February 2026

Quick facts

Lead sponsor	Phoenix Children's Hospital
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	142
Start date	11 May 2018
Primary completion	28 February 2025
Estimated completion	28 February 2026
Sites	10 locations across United States

Drugs / interventions tested

Transanastomotic Tube (5FR)
No Transanastomotic Tube

Conditions studied

Esophageal Atresia — all drugs for Esophageal Atresia →
Tracheoesophageal Fistula — all drugs for Tracheoesophageal Fistula →

Sponsor

Phoenix Children's Hospital

Who can join

Under 6 Months, any sex, with Esophageal Atresia or Tracheoesophageal Fistula. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This trial will compare the effectiveness of two common surgical practices for Type C esophageal atresia repair: esophageal atresia (EA) with distal tracheoesophageal fistula (TEF). Infants with EA/TEF requiring surgical intervention will be recruited. Subjects will be randomized to either repair with or without transanstomotic tube (TT) during esophageal anastomosis creation. Primary outcome is symptomatic anastomotic stricture development requiring dilation within 12 months.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Surgical repair of esophageal atresia: do trans-anastomotic feeding tubes have an impact on the outcome?
Batikhe MY, Redwan M, Gafar A, Ramadan M. · · 2025 · PMID 41321446 · DOI 10.3389/fped.2025.1685089

Verify or expand the search:

Other recruiting trials for Esophageal Atresia

Currently open trials in the same condition.

NCT06860919 — Prospective Evaluation of the Results of Multidisciplinary Follow-up After a Transitional Consultation for Esophageal At · recruiting
NCT06975982 — Symptoms, Pulmonary Function, Muscle Strength, Exercise Capacity, and Frailty in Esophageal Atresia vs. Healthy Peers · recruiting
NCT05995171 — Long Term Outcome of Easophageal Atresia : Transmics Profiles in Adolescence · recruiting

Other Phoenix Children's Hospital trials

Trials by the same sponsor.

NCT06372249 — A Clinical Trial of Soluble Fiber for Asthma · Phase 2 · recruiting
NCT05925075 — Point of Care Lung Ultrasound in Preterm Infants with Respiratory Distress · enrolling by invitation
NCT05563610 — Oral Penicillin Challenge and Allergy De-labeling in Children · Phase 4 · terminated
NCT04344652 — Photoscreening for Retinoblastoma · NA · withdrawn
NCT04040452 — Continuous vs Intermittent Ketorolac for Pain Control in Peds CV Surgery · Phase 4 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03730454 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Phoenix Children's Hospital
Last refreshed: 10 March 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03730454.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing