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NCT06061575
Comparison of the Efficacy of Paracetamol and Ibuprofen in the Management of Fever in Sepsis Patients
Phase 4 trial testing Acetaminophen in Sepsis in 113 participants. Completed in 1 December 2024.
31 October 2024
Quick facts
| Lead sponsor | Ankara City Hospital Bilkent |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 113 |
| Start date | 31 October 2023 |
| Primary completion | 31 October 2024 |
| Estimated completion | 1 December 2024 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Acetaminophen (Paracetamol) — full drug profile →
- Ibuprofen (ibuprofen) — full drug profile →
Conditions studied
- Sepsis — all drugs for Sepsis →
- Acetaminophen — all drugs for Acetaminophen →
- Fever — all drugs for Fever →
- Ibuprofen — all drugs for Ibuprofen →
Sponsor
Ankara City Hospital Bilkent
Who can join
Adults 18 to 80, any sex, with Sepsis or Acetaminophen. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a randomized double-blind controlled study with the primary aim of scientifically evaluating the potential effects of paracetamol and ibuprofen in the management of sepsis by comparing their fever-reducing efficacy in septic patients. Sepsis is recognized as a severe form of systemic inflammatory response syndrome (SIRS) characterized by organ dysfunction resulting from severe infections. This study aims to address a significant aspect of fever management in septic patients by objectively assessing the fever-reducing potential of paracetamol and ibuprofen.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06061575
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other Ankara City Hospital Bilkent trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06061575 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ankara City Hospital Bilkent
- Last refreshed: 4 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06061575.
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