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NCT06051825
Diagnostic Importance of the C-reactive Protein From Blood and Saliva in Children With Acute Appendicitis
trial testing Blood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels in Acute Appendicitis in 100 participants. Status unknown.
30 October 2024
Quick facts
| Lead sponsor | University Hospital of Split |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 1 November 2023 |
| Primary completion | 30 October 2024 |
| Estimated completion | 30 November 2024 |
Drugs / interventions tested
- Blood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels
Conditions studied
- Acute Appendicitis — all drugs for Acute Appendicitis →
Sponsor
University Hospital of Split
Who can join
Adults 5 to 17, any sex, with Acute Appendicitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Diagnosing acute appendicitis in children is still a challenge even for experienced clinicians. Failure to recognize this acute condition can result in perforation, with consequent peritonitis, or misdiagnosis can result in negative appendectomies. C-reactive protein in blood can be elavated in children with acute appendicitis. The aim of this research is to compare the diagnostic value of C-reactive protein from the blood and saliva of children with acute appendicitis and to prove wheter the analysis of biomarker from saliva as a minimally invasive procedure can be sufficient for diagnosis.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Salivary C-Reactive Protein: A Non-Invasive Alternative to Serum CRP in Pediatric Acute Appendicitis.
Milunović KP, Stanišić L, Barić T, Meštrović J, et al · · 2025 · cited 2× · PMID 40871545 · DOI 10.3390/molecules30163392
Verify or expand the search:
- PubMed search for NCT06051825
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acute Appendicitis
Currently open trials in the same condition.
- NCT07496723 — Comparison of Diagnostic Methods in Patients Operated for Suspected Appendicitis · recruiting
- NCT07008092 — Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children · recruiting
- NCT07492329 — Antibiotics vs Surgery in Acute Appendicitis · NA · active not recruiting
- NCT06563349 — Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy · Phase 4 · recruiting
- NCT03236961 — Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis · NA · active not recruiting
Other University Hospital of Split trials
Trials by the same sponsor.
- NCT07130006 — Preoperative Use of Peripheral Nerve Blocks in Elderly Patients With Hip Fractures · Phase 4 · not yet recruiting
- NCT06595329 — Comparison Between Epidural Analgesia and Intrathecal Opioid Analgesia for Pain Management in Open Nephrectomy · Phase 1 · recruiting
- NCT06399445 — Measurement of Blood Loss in Adenotonsillectomy During General Anesthesia According to the Application of Nondepolarizin · Phase 4 · recruiting
- NCT05537272 — The Efficacy of Tamsulosin and Tadalafil Compared to Placebo in the Treatment and Prevention of Urinary Disorders After · Phase 4 · unknown
- NCT05202600 — Justification of Incidental Appendectomy With Respect to Pathohistological Findings · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06051825 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital of Split
- Last refreshed: 25 September 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06051825.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing