NCT06048887 is a Phase 1 clinical trial of CRN04894 Oral Solution in Healthy Volunteers, sponsored by Crinetics Pharmaceuticals Inc..

Who is sponsoring NCT06048887?

NCT06048887 is sponsored by Crinetics Pharmaceuticals Inc..

What drugs are being tested in NCT06048887?

Interventions in NCT06048887: CRN04894 Oral Solution, Placebo Oral Solution.

What condition does NCT06048887 study?

NCT06048887 studies Healthy Volunteers.

Is NCT06048887 still recruiting?

NCT06048887 is currently completed. Last updated 21 September 2023.

Last reviewed 2023-09-21 · How we verify

NCT06048887

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Single and Multiple-Ascending Dose Study of CRN04894 in Healthy Volunteers

Completed Phase 1 Last updated 21 September 2023

What this trial tests

Phase 1 trial testing CRN04894 Oral Solution in Healthy Volunteers in 88 participants. Completed in 11 April 2022.

Timeline

18 December 2020

Primary endpoint
11 April 2022

11 April 2022

Quick facts

Lead sponsor	Crinetics Pharmaceuticals Inc.
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	88
Start date	18 December 2020
Primary completion	11 April 2022
Estimated completion	11 April 2022
Sites	1 location across United States

Drugs / interventions tested

CRN04894 Oral Solution — full drug profile →
Placebo Oral Solution

Conditions studied

Healthy Volunteers — all drugs for Healthy Volunteers →

Sponsor

Crinetics Pharmaceuticals Inc. — full company profile →

Who can join

Adults 18 to 55, any sex, with Healthy Volunteers. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A Phase 1, first-in-human, double-blind, randomized, placebo-controlled study to evaluate the safety of CRN04894 in healthy volunteers as well as the relationship between exposure and pharmacodynamic (PD) parameters.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Future Directions in the Management of Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.
Sarafoglou K, Auchus RJ. · · 2025 · cited 11× · PMID 39836617 · DOI 10.1210/clinem/dgae759

Verify or expand the search:

Other recruiting trials for Healthy Volunteers

Currently open trials in the same condition.

NCT07504003 — Influence of Training Session Duration on Improvements in Physiological Resilience to Exercise · NA · recruiting
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NCT07495813 — A Study to See How RO7763505 Works and How Safe it is When Given to Healthy People and People With Stable Heart Disease · Phase 1 · recruiting
NCT07499050 — A Study of Multiple Doses of Orally Administered RO7795081 in Otherwise Healthy Chinese Adult Participants With Obesity · Phase 1 · recruiting
NCT07342114 — A Dose-Escalation Study of RO7875913 in Healthy Participants · Phase 1 · recruiting

Other Crinetics Pharmaceuticals Inc. trials

Trials by the same sponsor.

NCT07221084 — A Study to Assess Pharmacokinetics, Safety, and Tolerability of Atumelnant in Healthy Japanese and Caucasian Participant · Phase 1 · completed
NCT05907291 — Evaluate the Safety, Efficacy, and Pharmacokinetics of CRN04894 in Participants With Congenital Adrenal Hyperplasia (Tou · Phase 2 · completed
NCT05361668 — Study to Evaluate the Safety, PK, and Dose Response of Paltusotine in Subjects With Carcinoid Syndrome · Phase 2 · completed
NCT04246749 — Mass Balance and Pharmacokinetics of [14C]-CRN00808 in Healthy Volunteers · Phase 1 · completed
NCT03936166 — A Single and Multiple-Ascending Dose Study of CRN01941 in Healthy Adult Volunteers · Phase 1 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06048887 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Crinetics Pharmaceuticals Inc.
Last refreshed: 21 September 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06048887.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing