NCT06038682 is a clinical trial of Argatroban Injection in ARDS, sponsored by University Hospital Ostrava.

Who is sponsoring NCT06038682?

NCT06038682 is sponsored by University Hospital Ostrava.

What drugs are being tested in NCT06038682?

Interventions in NCT06038682: Argatroban Injection, Heparin.

What condition does NCT06038682 study?

NCT06038682 studies ARDS, COVID-19.

Is NCT06038682 still recruiting?

NCT06038682 is currently completed. Last updated 1 March 2024.

Last reviewed 2024-03-01 · How we verify

NCT06038682

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Monitoring Anticoagulation in Patients on ECMO for Severe Lung Failure

Completed Last updated 1 March 2024

What this trial tests

trial testing Argatroban Injection in ARDS in 100 participants. Completed in 31 December 2023.

Timeline

1 April 2020

Primary endpoint
31 July 2023

31 December 2023

Quick facts

Lead sponsor	University Hospital Ostrava
Status	Completed
Study type	OBSERVATIONAL
Enrollment	100
Start date	1 April 2020
Primary completion	31 July 2023
Estimated completion	31 December 2023
Sites	1 location across Czechia

Drugs / interventions tested

Argatroban Injection — full drug profile →
Heparin (HEPARIN) — full drug profile →

Conditions studied

ARDS — all drugs for ARDS →
COVID-19 — all drugs for COVID-19 →

Sponsor

University Hospital Ostrava

Who can join

Adults 18 to 80, any sex, with ARDS or COVID-19. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A monocentric observational study evaluates the accuracy of anticoagulation monitoring in critically ill patients on ECLS (extracorporeal life support) using new markers of the effect of direct thrombin inhibitors and also the accuracy of anticoagulation monitoring in patients on unfractionated heparin using anti-Xa. A more accurate setting of anticoagulation may lead to a reduction in the number of serious bleeding and thrombotic complications in these patients.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

A safety comparison of heparin and argatroban anticoagulation in veno-venous extracorporeal membrane oxygenation with a focus on bleeding.
Burša F, Máca J, Sagan J, Sklienka P, et al · · 2025 · cited 5× · PMID 39375884 · DOI 10.1111/tme.13102
Activated Partial Thromboplastin Time and Anti-IIa Monitoring in Argatroban Anticoagulation in COVID-19 Patients on Venovenous Extracorporeal Membrane Oxygenation.
Burša F, Frelich M, Sklienka P, Němcová S, et al · · 2025 · PMID 40396972 · DOI 10.1177/10760296251341315

Verify or expand the search:

Other recruiting trials for ARDS

Currently open trials in the same condition.

NCT07362537 — Enteral Nutrition Delivery in Prone Position Ventilated Patients With Moderate to Severe ARDS · NA · recruiting
NCT07298889 — High PEEP in Noninvasive Ventilation Patients With Pneumonia or ARDS · NA · recruiting
NCT07193719 — Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children · Phase 1, PHASE2 · recruiting
NCT07370610 — Electrical Impedance Tomography-Based Dynamic Ventilation-Perfusion Functional Phenotype Trajectory in Acute Respiratory · active not recruiting
NCT06647784 — Lateral Positioning and Prone Positioning in ARDS Patients · NA · recruiting

Other University Hospital Ostrava trials

Trials by the same sponsor.

NCT07177183 — Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure · NA · recruiting
NCT07374289 — On Scene ECPR in Ostrava · NA · recruiting
NCT07041086 — Prehospital ECPR in Moravia Silesia Region · recruiting
NCT07009652 — Optimization of Transport and Use of a Mobile ECMO Team in Patients With Sudden Cardiac Arrest in the Moravian-Silesian · recruiting
NCT06921746 — Changes in the Urinary Microbiome and Metabolome During Treatment of the Overactive Bladder in Female Patients · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06038682 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital Ostrava
Last refreshed: 1 March 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06038682.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing