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NCT06036095: TIVA GAS
Total Intravenous Versus Inhalational Anesthesia- A Geriatric Anesthesia Study
Phase 4 trial testing Sevoflurane in Neurocognitive Disorders in 260 participants. Currently enrolling.
15 March 2027
Quick facts
| Lead sponsor | Oregon Health and Science University |
|---|---|
| Phase | Phase 4 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 260 |
| Start date | 14 August 2023 |
| Primary completion | 15 March 2027 |
| Estimated completion | 15 March 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Sevoflurane — full drug profile →
- Propofol (Propofol) — full drug profile →
Conditions studied
- Neurocognitive Disorders — all drugs for Neurocognitive Disorders →
- Anesthesia — all drugs for Anesthesia →
- Post-operative Delirium — all drugs for Post-operative Delirium →
- Post-operative Cognitive Dysfunction — all drugs for Post-operative Cognitive Dysfunction →
Sponsor
Oregon Health and Science University
Who can join
Adults 70 to 110, any sex, with Neurocognitive Disorders or Anesthesia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Traditionally, general anesthesia is maintained with inhalational anesthesia (GAS), but there is a gap in knowledge regarding whether intravenous anesthesia (IV) can prevent deleterious postoperative outcomes in the geriatric surgical population. The goal of this clinical trial is to determine whether intravenous anesthesia (IV) leads to a decreased incidence of postoperative delirium (POD), postoperative cognitive dysfunction (POCD), and functional decline, and improved patient-reported outcomes (PROs) in older adults undergoing non-cardiac surgery when compared to the standard inhalational anesthesia (GAS). This single-center, 1:1 randomized, double-blind (patient \& outcome assessor) clinical trial will compare inhalational vs. intravenous anesthesia on POD, POCD, functional status, patient-reported outcomes (PROs), and blood-based biomarkers in older patients undergoing elective, inpatient, non-cardiac surgery. Upon enrollment, 260 women and men ≥ 70 years undergoing elective noncardiac surgery under general anesthesia will be randomized to 2 groups: TIVA or GAS.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06036095
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06036095 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Oregon Health and Science University
- Last refreshed: 8 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06036095.
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