NCT06035991 (PEGASE) is a NA clinical trial of Heart transplantation in Heart Transplantation, sponsored by Assistance Publique - Hôpitaux de Paris.

Who is sponsoring NCT06035991?

NCT06035991 is sponsored by Assistance Publique - Hôpitaux de Paris.

What drugs are being tested in NCT06035991?

Interventions in NCT06035991: Heart transplantation.

What condition does NCT06035991 study?

NCT06035991 studies Heart Transplantation.

Is NCT06035991 still recruiting?

NCT06035991 is currently active, enrolled. Last updated 19 March 2026.

Last reviewed 2026-03-19 · How we verify

NCT06035991: PEGASE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

First Clinical Evaluation of Heart Transplantation With Grafts Preserved Using an Ex-vivo Extended Perfusion System

Active, enrolled NA Last updated 19 March 2026

What this trial tests

NA trial testing Heart transplantation in Heart Transplantation in 20 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

28 October 2023

Primary endpoint
30 October 2027

30 October 2028

Quick facts

Lead sponsor	Assistance Publique - Hôpitaux de Paris
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	20
Start date	28 October 2023
Primary completion	30 October 2027
Estimated completion	30 October 2028
Sites	1 location across France

Drugs / interventions tested

Heart transplantation

Conditions studied

Heart Transplantation — all drugs for Heart Transplantation →

Sponsor

Assistance Publique - Hôpitaux de Paris — full company profile →

Who can join

Adults 18 to 100, any sex, with Heart Transplantation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The main objective of PEGASE is to validate the recovery of a satisfactory cardiac function of a transplanted heart after a prolonged period of preservation by an ex-vivo perfusion device. This recovery of cardiac function will have to happen within 15 days after transplantation.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Clinical Outcomes of Machine Perfusion and Temperature Control Systems in Heart Transplantation: Where We Stand.
Nasim U, Dorken-Gallastegi A, Dadson P, Hong Y. · · 2025 · cited 5× · PMID 40004682 · DOI 10.3390/jcm14041152

Verify or expand the search:

Other recruiting trials for Heart Transplantation

Currently open trials in the same condition.

NCT07359690 — Multimodal Analysis of Endomyocardial Biopsies · recruiting
NCT07096973 — Cardiac REhabilitation COhort at the Medicine Campus DaVos to invEstigate Recovery · recruiting
NCT07372820 — METABolic Deterioration in HTX Determines Outcomes · recruiting
NCT06982404 — ZeroHeart Biopsy - Prediction of Deceased Donor Heart Transplant Performance From Organ Donors Using Pre-Transplant Biop · recruiting
NCT07531784 — A National Swedish Study Evaluating Dd-cfDNA for as a Diagnostic Biomarker for Rejection Surveillence in Heart Transplan · recruiting

Other Assistance Publique - Hôpitaux de Paris trials

Trials by the same sponsor.

NCT07443436 — Immunomodulatory Treatment of Interstitial Lung Disease Associated With Surfactant Related Gene Variants · Phase 2 · not yet recruiting
NCT07499492 — Red Blood Cell Transfusion to Optimize Extubation · NA · not yet recruiting
NCT07379918 — Real-life Evaluation of Endopredict® in Early HR+/HER2- Breast Cancer · recruiting
NCT07473869 — Smartphone Application for Automated Measurement of Capillary Refill Time (CRT) · not yet recruiting
NCT07505394 — Efficacy of a Prediction Model-based Algorithm to PREVENT Drug-induced Impulse Control Disorders in Parkinson's Disease · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06035991 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Assistance Publique - Hôpitaux de Paris
Last refreshed: 19 March 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06035991.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing