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NCT06019364: HEPEP
Transfusion of Whole Blood in Acute Bleeding
trial testing Whole blood transfusion in Blood Transfusion in 150 participants. Enrolling by invitation.
1 August 2030
Quick facts
| Lead sponsor | Sofia Ramström |
|---|---|
| Status | ENROLLING BY INVITATION |
| Study type | OBSERVATIONAL |
| Enrollment | 150 |
| Start date | 10 September 2023 |
| Primary completion | 1 August 2030 |
| Estimated completion | 1 August 2031 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Whole blood transfusion — full drug profile →
Conditions studied
- Blood Transfusion — all drugs for Blood Transfusion →
- Acute Bleeding — all drugs for Acute Bleeding →
Sponsor
Sofia Ramström
Who can join
18 and older, any sex, with Blood Transfusion or Acute Bleeding. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Blood collected from blood donors is routinely divided into its different components, red blood cells, plasma and platelets. These components are stored under different storage conditions and their maximum storage time before transfusion is different. Platelets are stored at a maximum of 7 days and at a temperature of 22°C to best preserve their function. Research has been conduction on blood stored and transfused as whole blood (without separation into the various components), particularly in situations of acute trauma. Region Örebro län will therefore start transfusion of whole blood in such situations. The whole blood units will be stored at 4°C for a maximum of 14 days. This means that the platelets will be stored at a lower temperature than standard and for a longer time period. The research on how this will affect platelet function is limited. This project aims to determine how the patients are affected regarding coagulation, hemolysis, renal function, immunisation, transfusion reactions and the effect of substances released from the blood cells in the whole blood units during the storage period and if there is an impact on mortality.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06019364
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
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Trials testing the same drug.
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- NCT05744583 — Finnish Prehospital Whole Blood Study · NA · recruiting
- NCT04431999 — Evaluation of a Transfusion Therapy Using Whole Blood in the Management of Coagulopathy in Patients With Acute Traumatic · Phase 3 · completed
Other recruiting trials for Blood Transfusion
Currently open trials in the same condition.
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- NCT06142825 — Developing, Implementing and Evaluating Effective Community-facility Interactions to Improve Blood Availability and Tran · NA · active not recruiting
- NCT06102590 — Oxygen Extraction-guided Transfusion · NA · recruiting
Other Sofia Ramström trials
Trials by the same sponsor.
- NCT05038722 — Function of Platelets Used for Transfusions · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06019364 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sofia Ramström
- Last refreshed: 1 November 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06019364.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing