NCT06007053: ReACT

Retraining and Control Therapy (ReACT) R33 Phase

Recruiting now NA Last updated 17 March 2026

What this trial tests

NA trial testing ReACT in Convulsion, Non-Epileptic in 160 participants. Currently enrolling.

Timeline

9 March 2024

Primary endpoint
31 December 2026

31 December 2026

Quick facts

Lead sponsor	University of Alabama at Birmingham
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	160
Start date	9 March 2024
Primary completion	31 December 2026
Estimated completion	31 December 2026
Sites	1 location across United States

Drugs / interventions tested

• ReACT
• Supportive Therapy

Conditions studied

• Convulsion, Non-Epileptic — all drugs for Convulsion, Non-Epileptic →

Sponsor

University of Alabama at Birmingham

Who can join

Adults 11 to 18, any sex, with Convulsion, Non-Epileptic. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to assess sense of control and catastrophic symptom expectations as targets for Retraining and Control Therapy (ReACT- an intervention focused on changing behaviors and thoughts) for treatment of pediatric psychogenic non-epileptic seizures (PNES, episodes resembling epileptic seizures but with no correlated epileptiform activity). 11-18-year-olds diagnosed with PNES will engage in twelve sessions of either ReACT or supportive therapy. Sense of control over actions will be measured by the magic and turbulence task, a well-validated measure of sense of control. Participants will complete the cold pressor test (CPT) in which participants hold their hand in cool water for as long as possible up to 3 minutes. Catastrophic symptom expectations in response to the CPT will be measured by Pain Catastrophizing Scale for Children (PCS-C), pain tolerance (time with hand in water) and cortisol response. Target assessments occur 7 days before treatment, 7 days after 12th treatment session, and 2 months after the 12th treatment session. Long term follow-up assessments will occur 6 months and 12 months after the 12th treatment session. PNES frequency will be measured from 30 days before to 12 months after treatment.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Retraining and control therapy: sense of control and catastrophic symptom expectations as targets of a cognitive behavioral treatment for pediatric functional seizures.
   Watson C, Valaiyapathi B, Szaflarski JP, Goodin BR, et al · · 2025 · PMID 41769205 · DOI 10.3389/fpsyt.2025.1610446