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NCT05997095: PoEMS
Post-operative Electrical Muscle Stimulation to Stimulate Muscle Protein Synthesis in Humans
NA trial testing Neuromuscular electrical stimulation (NMES/0 in Skeletal Muscle Atrophy in 10 participants. Participants enrolled and being followed up; not accepting new ones.
28 September 2025
Quick facts
| Lead sponsor | University of Nottingham |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 10 |
| Start date | 22 May 2023 |
| Primary completion | 28 September 2025 |
| Estimated completion | 28 December 2025 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Neuromuscular electrical stimulation (NMES/0
Conditions studied
- Skeletal Muscle Atrophy — all drugs for Skeletal Muscle Atrophy →
Sponsor
University of Nottingham
Who can join
Adults 60 to 85, any sex, with Skeletal Muscle Atrophy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Skeletal muscle accounts for approximately 45-55% of total body mass in healthy adults and plays a pivotal role in whole-body metabolic health, locomotion and physical independence. Undesirable loss of skeletal muscle mass (atrophy) is, however, a common feature of many communicable and non-communicable diseases including ageing, bed-rest/immobilisation, cancer and physical inactivity. As such, the design of optimal strategies (e.g., different types of exercise) to "offset" these detrimental losses of muscle is a focus for both researchers and clinicians. One situation where losses of muscle mass occur very quickly (i.e., within a few days) is after surgery. However, at this time, most people (especially if they have had major abdominal or lower-limb surgery) are not able to perform exercise and as such a different strategy to maintain muscle mass needs to be found. It has been shown that electrical stimulation of the leg muscles can maintain muscle mass and function in patients after surgery. It is not however yet known, what the optimal electrical stimulation regime is to preserve muscle mass during situations of disuse. This study aims to examine the impact of three different electrical stimulation protocols on muscle building processes in individuals age-matched to those most commonly presenting for major abdominal surgery. This information will then be used in a clinical trial of surgical patients to see if it can preserve their muscle mass and function in the post-operative period.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05997095
- Europe PMC full search
- ASCO Meeting Library
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Related trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05997095 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Nottingham
- Last refreshed: 2 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05997095.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing