Last reviewed · How we verify
NCT06573086: TraDeRe
Resistance Training, Detraining, and Retraining Study 2024 (TraDeRe2024)
NA trial testing Resistance Training in Hypertrophy in 90 participants. Currently enrolling.
15 June 2025
Quick facts
| Lead sponsor | University of Jyvaskyla |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 90 |
| Start date | 19 August 2024 |
| Primary completion | 15 June 2025 |
| Estimated completion | 15 June 2025 |
| Sites | 1 location across Finland |
Drugs / interventions tested
- Resistance Training
Conditions studied
- Hypertrophy — all drugs for Hypertrophy →
- Exercise Training — all drugs for Exercise Training →
- Skeletal Muscle Atrophy — all drugs for Skeletal Muscle Atrophy →
- Healthy — all drugs for Healthy →
Sponsor
University of Jyvaskyla
Who can join
Adults 18 to 50, any sex, with Hypertrophy or Exercise Training. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goals of our research project are to identify factors explaining inter-individual variation in responses to resistance training (RT) and the baseline determinants underlying an individual's sensitivity to respond to RT. Moreover, investigators aim to assess whether a responsiveness to RT predicts responsiveness to endurance training (ET). Thus, investigators aim to gain a deeper understanding of exercise adaptation processes. The main questions investigators aim to answer are: * Can the physiological responses of one RT intervention be extrapolated to a subsequent RT intervention? * If so, what are the mechanisms underlying differing skeletal muscle growth responses in low, and high responders of skeletal muscle hypertrophy? * If so, do the low responders of skeletal muscle growth respond more favourably when the amount of RT is increased? * Are the high, moderate, and low responders of RT also the highest, moderate, and lowest responders to ET? To examine these main research questions, high (n=30), low (n=30), and moderate (n=30) responders of skeletal muscle growth in response to RT (intervention I, NCT05874986) are reallocated into a subsequent 12-week RT intervention (intervention II) after a detraining period. A subgroup of these participants (n=10) will engage in a 6-week control period before starting the second RT period. Additionally, after intervention II, participants will participate in an ET intervention, lasting 6 weeks. In this intervention II, reallocated participants will be: * Resistance training with supervision for 12 weeks * Consuming deuterium oxide for the assessment of muscle protein synthesis * Consuming D3-3-methylhistidine for the assessment of acute muscle protein breakdown * Consuming D3-creatine for the examination of whole-body skeletal muscle mass * Providing a spot urine sample six (6) times, and urine collection for 24 hours performed twice * Providing saliva samples (30-32 in total) for the assessment of body water enrichment of deuterium * Providing a muscle biopsy four or five (4-5) times during the study * Providing a blood sample fourteen (14) times during the study * Assessed for body composition and body volume four or five times (4-5) during the study * Participating in muscle size, maximal dynamic strength and TMS measurements four or five (4-5) times during the study * Asked to answer questionnaires related to e.g. stress, physical activity, sleep, perceived exertion, and diet * Participating in recovery measurements before and after the second-to-last and the last RT bout, and once in the days between these RT bouts, consisting of six (6) body volume measurements and six (6) maximal voluntary isometric contraction (kg) tests using horizontal leg press for the assessment of neuromuscular recovery * Participating in an acute resistance exercise (RE) after the 12-week RT intervention. Furthermore, in the ET intervention, participants will be: * Participating in a familiarization session and resting electrocardiograph measurements before the intervention * Participating in endurance testing consisting of body composition, movement economy, and incremental RAMP testing before and after ET intervention * Endurance training with supervision for 6 weeks, three times a week.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06573086
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Resistance Training
Trials testing the same drug.
- NCT07135232 — The Effects of Resistance Training and a Plant-Based Supplement on Perimenopausal Symptoms and Muscle Health. · NA · recruiting
- NCT07278440 — An Exercise Intervention for Improving Mental and Physical Health in Patients With Primary Brain Tumors and Their Caregi · NA · not yet recruiting
- NCT07364149 — Acute Effects of Structured Exercise and Static Stretching on Vascular Function, Neuromuscular Performance, and Metaboli · NA · recruiting
- NCT07262931 — Effect Of Sensory Motor Training Versus Resistance Training Among Individuals With Knee Osteoarthritis. · NA · not yet recruiting
- NCT07045727 — Prehabilitation With Aerobic and Resistance Exercise for Improving Physical Fitness and Quality of Life Outcomes in Olde · NA · recruiting
Other recruiting trials for Hypertrophy
Currently open trials in the same condition.
- NCT05774444 — Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism · NA · recruiting
- NCT04514744 — Dynamic Proteomics and Integrated Rates of Muscle Protein Synthesis During an Acute Period of Loading and Unloading · NA · active not recruiting
Other University of Jyvaskyla trials
Trials by the same sponsor.
- NCT07500922 — Menopause Effects on Cortico-reticular Functioning · NA · not yet recruiting
- NCT07406412 — Hormonal Regulation of Cardiometabolic Health Study · not yet recruiting
- NCT05874986 — Why do People Respond Differently to Resistance Training? · NA · completed
- NCT05553769 — Resistance Training, Detraining, and Retraining Study 2022 · NA · completed
- NCT04997447 — Enforced Reduction in Physical Activity and Recovery in Older Adults · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06573086 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Jyvaskyla
- Last refreshed: 6 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06573086.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing