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NCT05989971
The Effect of Continuous Renal Replacement Therapy on the Efficiency of Extracorporeal CO2 Removal
trial testing continuous renal replacement therapy in Respiratory Failure With Hypercapnia in 10 participants. Completed in 31 December 2025.
31 December 2023
Quick facts
| Lead sponsor | Southeast University, China |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 10 |
| Start date | 24 April 2023 |
| Primary completion | 31 December 2023 |
| Estimated completion | 31 December 2025 |
| Sites | 1 location across China |
Drugs / interventions tested
- continuous renal replacement therapy — full drug profile →
Conditions studied
- Respiratory Failure With Hypercapnia — all drugs for Respiratory Failure With Hypercapnia →
Sponsor
Southeast University, China
Who can join
Adults 18 to 85, any sex, with Respiratory Failure With Hypercapnia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In the design of extracorporeal carbon dioxide removal (ECCO2R) combined with continuous renal replacement therapy (CRRT) equipment, in model of continuous veno-venous hemofiltration (CVVH) , the HCO3- concentration in the pre membrane lung blood is diluted by the replacement solution, and a decrease in HCO3- leads to a decrease in PCO2. On the other hand, in continuous veno-venous hemodialysis (CVVHD), HCO3- in post membrane blood will exchange interaction. The exchange results of HCO3- determine the impact of CVVHD on the CO2 removal efficiency of the ECCO2R combined CRRT system. This study aims to investigate the effects of CVVH and CVVHD on in vitro CO2 clearance efficiency.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effect of low bicarbonate substitution solution on CO<sub>2</sub> removal rate in the combined system of extracorporeal CO<sub>2</sub> removal and continuous renal replacement therapy.
Qian Z, Zhang R, Wang Y, He H, et al · · 2025 · cited 1× · PMID 41254306 · DOI 10.1186/s40635-025-00827-8
Verify or expand the search:
- PubMed search for NCT05989971
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of continuous renal replacement therapy
Trials testing the same drug.
- NCT07365111 — Insights Into the Continuous Renal Replacement Therapy to Critical Ill Patients · not yet recruiting
- NCT05349305 — Population Pharmacokinetics of Lassila Tazobactam in Patients After Aortic Dissection · unknown
- NCT06844435 — Continuous Renal Replacement Therapy (CRRT) in Surgery Room During Orthotopic Liver Transplantation (OLT) · NA · completed
Other recruiting trials for Respiratory Failure With Hypercapnia
Currently open trials in the same condition.
- NCT06918288 — Post-extubation Nasal Humidified High-flow Oxygen Versus Non-invasive Positive Pressure Ventilation · Phase 2 · active not recruiting
Other Southeast University, China trials
Trials by the same sponsor.
- NCT07519512 — Effect of Early Transition to Assisted Ventilation on 28-day Successful Extubation in Critically Ill Patients · NA · recruiting
- NCT06990477 — Effect of EIT-guided PEEP in ARDS Patients With Higher Recruitability · NA · recruiting
- NCT07362537 — Enteral Nutrition Delivery in Prone Position Ventilated Patients With Moderate to Severe ARDS · NA · recruiting
- NCT07327268 — Cyclic On-off Switching of Pulmonary Blood Flow in Moderate to Severe ARDS · not yet recruiting
- NCT07284888 — Practices of Prone Positioning Ventilation in Patients With Moderate-to-Severe ARDS in Intensive Care Units: A Registry- · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05989971 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Southeast University, China
- Last refreshed: 22 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05989971.
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