Last reviewed · How we verify
NCT05985928: SweetTaste
Sensory Study: Taste and Tongue Biology
trial in Healthy Adults in 121 participants. Completed in 20 May 2025.
20 April 2025
Quick facts
| Lead sponsor | University of Massachusetts, Amherst |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 121 |
| Start date | 20 March 2023 |
| Primary completion | 20 April 2025 |
| Estimated completion | 20 May 2025 |
| Sites | 1 location across United States |
Conditions studied
- Healthy Adults — all drugs for Healthy Adults →
Sponsor
University of Massachusetts, Amherst
Who can join
Adults 18 to 45, any sex, with Healthy Adults. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Researchers will investigate the correlation between a) self-reported dietary intake of foods and beverages, b) intensity of sucrose stimuli, and c) liking rating of sweet stimuli, with the relative expression of the taste receptor genes from human fungiform papillae (TAS1R2 and TAS1R3). \* This research will provide new information on how sweet taste perception is regulated. * The hypothesis: Greater dietary consumption of sugar and sweet foods is associated with reduced expression of the sweet taste receptors. * The results of this study could help to identify pathways to help modify sweet taste perception by uncovering this mechanism. Participants will sample solutions prepared with sweet ingredients, provide salivary DNA, and collect fungiform papillae. This will allow researchers and investigators to compare the relationship between the sweetness of stimuli, genetic differences in sweet taste receptors, and expression levels of sweet taste receptor genes.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05985928
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05985928 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Massachusetts, Amherst
- Last refreshed: 5 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05985928.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing