Who is sponsoring NCT05979883?

NCT05979883 is sponsored by Mayo Clinic.

What drugs are being tested in NCT05979883?

Interventions in NCT05979883: Machine Learning Assisted Radiation (MLAP) RapidPlan, Radiation Therapy Standard of Care (SOC).

What condition does NCT05979883 study?

NCT05979883 studies Cancer Head Neck, Cancer, Head, Cancer Neck.

Is NCT05979883 still recruiting?

NCT05979883 is currently completed. Last updated 26 January 2026.

Last reviewed 2026-01-26 · How we verify

NCT05979883

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Randomized Evaluation of Machine Learning Assisted Radiation Treatment Planning vs Standard Radiation Treatment Planning

Completed NA Last updated 26 January 2026

What this trial tests

NA trial testing Machine Learning Assisted Radiation (MLAP) RapidPlan in Cancer Head Neck in 204 participants. Completed in 29 October 2025.

Timeline

7 August 2023

Primary endpoint
29 October 2025

29 October 2025

Quick facts

Lead sponsor	Mayo Clinic
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	204
Start date	7 August 2023
Primary completion	29 October 2025
Estimated completion	29 October 2025
Sites	6 locations across United States

Drugs / interventions tested

Machine Learning Assisted Radiation (MLAP) RapidPlan
Radiation Therapy Standard of Care (SOC)

Conditions studied

Cancer Head Neck — all drugs for Cancer Head Neck →
Cancer, Head — all drugs for Cancer, Head →
Cancer Neck — all drugs for Cancer Neck →

Sponsor

Mayo Clinic

Who can join

18 and older, any sex, with Cancer Head Neck or Cancer, Head. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to determine the magnitude of clinical benefit achieved through machine learning assisted radiation treatment planning (MLAP) on post-treatment clinical outcomes such as acute toxicity and patient reported outcomes.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Radiation-Induced Fibrosis (RIF) in Head and Neck Squamous Cell Carcinoma (HNSCC): A Review.
Muehlebach ME, Pradeep S, Chen X, Arnold L, et al · · 2025 · PMID 41439988 · DOI 10.3390/cells14241969
Beyond Standard Radiotherapy: an AI-Driven Framework for Personalized Radiotherapy with a Four-Step Classification in Head and Neck Squamous Cell Carcinoma (HNSCC) Patients.
Guo Y, Aboagye EO, Gujral DM. · · 2025 · PMID 41174258 · DOI 10.1007/s11912-025-01730-x

Verify or expand the search:

Other recruiting trials for Cancer Head Neck

Currently open trials in the same condition.

NCT05653063 — ARCHERY - Artificial Intelligence Based Radiotherapy Treatment Planning for Cervical, Head and Neck and Prostate Cancer · recruiting
NCT05987579 — Surgical Treatment of Stage T3 Squamous Cell Carcinomas of the Scalp · active not recruiting

Other Mayo Clinic trials

Trials by the same sponsor.

NCT07126548 — A Point of Prostate Cancer Diagnosis Virtual Reality Assistant Intervention in Supporting Newly Diagnosed Black Men · NA · not yet recruiting
NCT07221656 — Evaluation of Prolonged Asparaginase Activity Levels After Calaspargase Pegol Administration · not yet recruiting
NCT06891001 — The Utilization of a Shoe Insert on Individuals With Unilateral Greater Trochanteric Pain Syndrome on Single Leg Stance, · NA · not yet recruiting
NCT07169799 — Impact of Cryotherapy Spray (Tru-Freeze) for the Eradication of Gastric Antral Vascular Ectasia (ICE-GAVE) · NA · recruiting
NCT07086183 — Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05979883 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
Last refreshed: 26 January 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05979883.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing