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NCT05970393
Inspiratory Contribution of Pressure Support-ventilated Patients in Different PMI Conditions
NA trial testing pressure support level tatrition in Mechanical Ventilation in 22 participants. Completed in 1 January 2024.
1 December 2023
Quick facts
| Lead sponsor | Jian-Xin Zhou |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 22 |
| Start date | 7 February 2023 |
| Primary completion | 1 December 2023 |
| Estimated completion | 1 January 2024 |
| Sites | 1 location across China |
Drugs / interventions tested
- pressure support level tatrition
Conditions studied
- Mechanical Ventilation — all drugs for Mechanical Ventilation →
Sponsor
Jian-Xin Zhou
Who can join
Adults 18 to 80, any sex, with Mechanical Ventilation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Pressure support ventilation (PSV) is an assisted mechanical ventilation mode that provides synchronous inspiratory support for patients with spontaneous breathing. PSV divides the work involved in producing ventilation between the ventilator and the patients. The patient inspiratory effort needs close monitoring to avoid inappropriate assistance and maintain favorable patient-ventilator interaction during PSV. Esophageal pressure (Pes)-derived parameters are regarded as golden indicators of inspiratory effort. Based on this precondition, the fraction of PTP generated by the patient during PSV (PTP ratio) can evaluate the inspiratory contribution proportion of ventilated patients with spontaneous breathing. Inspiratory muscle pressure index (PMI) was confirmed to be associated with inspiratory effort and can effectively predict low/high effort. The study tries to explore the relationship between PMI and PTP ratio and find the optimal cut-off value of PMI to predict different PTP ratios. Second, investigators want to verify the safety and validity of PMI-guided PS settings for pressure-support ventilated patients.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Use of pressure muscle index to predict the contribution of patient's inspiratory effort during pressure support ventilation: a prospective physiological study.
Gao R, Zhou JX, Yang YL, Xu SS, et al · · 2024 · cited 4× · PMID 38737762 · DOI 10.3389/fmed.2024.1390878
Verify or expand the search:
- PubMed search for NCT05970393
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Mechanical Ventilation
Currently open trials in the same condition.
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- NCT06994442 — Optimizing Pain Treatment in Children On Mechanical Ventilation · Phase 3 · recruiting
- NCT07193719 — Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children · Phase 1, PHASE2 · recruiting
Other Jian-Xin Zhou trials
Trials by the same sponsor.
- NCT07129174 — Pulmonary Microbiota Changes and Clinical Outcomes in Neurosurgical ICU Patients With Artificial Airways · not yet recruiting
- NCT06968793 — Use of Endotracheal Tube Cuff Pressure to Assess Inspiratory Effort During Pressure Support Ventilation · NA · completed
- NCT06970990 — Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments · NA · recruiting
- NCT06816706 — Comparison of Physiological Effects of Two High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials · NA · recruiting
- NCT06816745 — Comparison of Physiological Effects of Two Types of High-Flow Oxygen Therapy in Tracheostomized Patients · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05970393 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Jian-Xin Zhou
- Last refreshed: 25 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05970393.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing