Who is sponsoring NCT06816706?

NCT06816706 is sponsored by Jian-Xin Zhou.

What drugs are being tested in NCT06816706?

Interventions in NCT06816706: Modified high flow tracheal oxygen-40L/min, Standard high flow tracheal oxygen-40L/min, T-piece, Modified high-flow tracheal oxygen-60L/min, Standard high-flow tracheal oxygen-60 L/min.

What condition does NCT06816706 study?

NCT06816706 studies Critical Care, Oxygen Therapy, Mechanical Ventilation.

Is NCT06816706 still recruiting?

NCT06816706 is currently recruiting now. Last updated 21 March 2025.

Last reviewed 2025-03-21 · How we verify

NCT06816706

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison of Physiological Effects of Two High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials

Recruiting now NA Last updated 21 March 2025

What this trial tests

NA trial testing Modified high flow tracheal oxygen-40L/min in Critical Care in 20 participants. Currently enrolling.

Timeline

1 March 2025

Primary endpoint
30 November 2025

30 December 2025

Quick facts

Lead sponsor	Jian-Xin Zhou
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	treatment
Enrollment	20
Start date	1 March 2025
Primary completion	30 November 2025
Estimated completion	30 December 2025
Sites	1 location across China

Drugs / interventions tested

Modified high flow tracheal oxygen-40L/min
Standard high flow tracheal oxygen-40L/min
T-piece
Modified high-flow tracheal oxygen-60L/min
Standard high-flow tracheal oxygen-60 L/min

Conditions studied

Critical Care — all drugs for Critical Care →
Oxygen Therapy — all drugs for Oxygen Therapy →
Mechanical Ventilation — all drugs for Mechanical Ventilation →

Sponsor

Jian-Xin Zhou

Who can join

18 and older, any sex, with Critical Care or Oxygen Therapy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Spontaneous breathing trials (SBT) are essential for assessing extubation tolerance, yet optimal approaches are debated. High-flow nasal oxygen offers benefits like precise oxygen delivery, flow-related positive end-expiratory pressure generation and improved lung function. While high-flow tracheal oxygen can also be used as an SBT method, it has reduced physiological effects due to bypassing the upper airway with a more open circuit. To enhance this limitation, investigators developed a modified high-flow tracheal oxygen tube with a smaller expiratory end diameter to increase expiratory resistance and airway pressure. This is a prospective randomized crossover study that aims to compare the physiological effects of standard and modified high-flow tracheal oxygen versus T-piece during SBT.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Physiological effects of high-flow oxygen via endotracheal tube versus T-piece strategies during spontaneous breathing trials: a study protocol and statistical analysis for a single-centre randomised crossover study.
Xu SS, Zhang RZ, An X, Miao MY, et al · · 2025 · PMID 40962338 · DOI 10.1136/bmjopen-2025-105360

Verify or expand the search:

Other recruiting trials for Critical Care

Currently open trials in the same condition.

NCT06526598 — Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial · NA · recruiting
NCT06457555 — Knowledge Levels and Experiences of Intensive Care Nurses on the Prevention of Pressure Sores: Mixed Method · active not recruiting
NCT06970990 — Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments · NA · recruiting
NCT06862700 — Effect of Reduced Vasopressors on Mortality in ECMO-supported Cardiogenic Shock Patients · recruiting
NCT07510776 — UP STUDY - Decipher Persistent Critical Illness Through in Deep Clinical Phenotyping. · recruiting

Other Jian-Xin Zhou trials

Trials by the same sponsor.

NCT07129174 — Pulmonary Microbiota Changes and Clinical Outcomes in Neurosurgical ICU Patients With Artificial Airways · not yet recruiting
NCT06968793 — Use of Endotracheal Tube Cuff Pressure to Assess Inspiratory Effort During Pressure Support Ventilation · NA · completed
NCT06970990 — Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments · NA · recruiting
NCT06816745 — Comparison of Physiological Effects of Two Types of High-Flow Oxygen Therapy in Tracheostomized Patients · NA · not yet recruiting
NCT05950893 — The Clinical Feasibility and Validity of PMIvent to Access Inspiratory Effort During Pressure Support Ventilation · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06816706 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Jian-Xin Zhou
Last refreshed: 21 March 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06816706.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing