Last reviewed · How we verify
NCT05963321: ctDCS
Cortical Excitability Modulation With ctDCS in Fibromyalgia.
NA trial testing TDCS in Fibromyalgia in 92 participants. Participants enrolled and being followed up; not accepting new ones.
31 December 2024
Quick facts
| Lead sponsor | Hospital de Clinicas de Porto Alegre |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 92 |
| Start date | 15 June 2023 |
| Primary completion | 31 December 2024 |
| Estimated completion | 1 April 2026 |
| Sites | 2 locations across Brazil |
Drugs / interventions tested
- TDCS — full drug profile →
Conditions studied
- Fibromyalgia — all drugs for Fibromyalgia →
- Chronic Pain — all drugs for Chronic Pain →
Sponsor
Hospital de Clinicas de Porto Alegre
Who can join
Adults 18 to 65, female only, with Fibromyalgia or Chronic Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Fibromyalgia is a syndrome characterized by chronic generalized musculoskeletal pain, accompanied by other symptoms such as fatigue, sleep disturbance and depression. Complaints of memory deficit, cognitive dysfunction, headache and gastrointestinal disorders are also common. Although it is a relatively common syndrome, exist a limited effectiveness of the pharmacologycal treatment. However, In the last years new therapeutic and diagnostic options have been sought. This scenario includes the use of different techniques of non-invasive brain stimulation, such as transcranial direct current magnetic stimulation (tDCS) and transcranial magnetic stimulation (TMS), which have already had promising results in reducing pain. Based on the above, the objective of this research is to evaluate the effect of cerebellar tDCS on clinical measures of pain and cortical excitability in patients with fibromyalgia. In this study, the intervention consists of a single tDCS session in which two devices will be used simultaneously. The active electrode will be placed in the cerebellum and/or in the primary motor cortex and the cathode in the contralateral supraorbital region. It is expected that the application of this protocol will be able to have a modulatory effect on clinical pain measures. In addition to producing changes in cortical excitability as a reflection of the integration between the cerebellum-thalamus-cortical pathways.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Cortical excitability and analgesic effects of multisite transcranial direct current stimulation targeting the motor cortex and cerebellum in fibromyalgia.
Betancur DFA, da Graça Lopes Tarragó M, França BR, Bueno GB, et al · · 2025 · PMID 41130992 · DOI 10.1038/s41598-025-20769-1
Verify or expand the search:
- PubMed search for NCT05963321
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other Hospital de Clinicas de Porto Alegre trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05963321 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital de Clinicas de Porto Alegre
- Last refreshed: 14 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05963321.
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