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NCT05960448
Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury
NA trial testing Transcutaneous Spinal Cord Stimulation (TSCS) in Orthostatic Hypotension in 20 participants. Currently enrolling.
30 July 2026
Quick facts
| Lead sponsor | James J. Peters Veterans Affairs Medical Center |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 20 |
| Start date | 30 July 2023 |
| Primary completion | 30 July 2026 |
| Estimated completion | 30 July 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Transcutaneous Spinal Cord Stimulation (TSCS)
- Sham Transcutaneous Spinal Cord Stimulation
Conditions studied
- Orthostatic Hypotension — all drugs for Orthostatic Hypotension →
Sponsor
James J. Peters Veterans Affairs Medical Center
Who can join
18 and older, any sex, with Orthostatic Hypotension. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this interventional crossover study is to determine the effects of transcutaneous spinal cord stimulation (TSCS) on the ability to perform moderate exercise and regulate core body temperature in the chronic spinal cord injury community. The main questions it aims to answer are: * What are the effects of active TSCS targeted for BP control on exercise endurance time and HR recovery during submaximal arm cycle ergometry (ACE) as compared to sham TSCS in participants with chronic, cervical SCI? * What are the effects of active TSCS on Tcore responses to cool ambient exposure and on subjective reporting of thermal comfort and thermal sensitivity as compared to sham TSCS. Participants will receive sham and active stimulation while using an arm bicycle or while in a cold room. Participants are free to participate in either the exercise phase, the cold room phase, or both phases of this study. Please note that there no expected long term benefits of this study.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Strategies to Augment the Cardiovascular System and Acutely Enhance Exercise Performance in Individuals with Spinal Cord Injury: A Systematic Scoping Review.
Hodgkiss DD, Balthazaar SJT, Gee CM, Chiou SY, et al · · 2025 · PMID 41196455 · DOI 10.1186/s40798-025-00909-7
Verify or expand the search:
- PubMed search for NCT05960448
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Orthostatic Hypotension
Currently open trials in the same condition.
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- NCT07196397 — POLish Registry of CArdioneuroablation and CArdioneuromodulation · recruiting
- NCT06439498 — Frequency of Orthostatic Hypotension in Patients Who Underwent Colonoscopy · active not recruiting
- NCT05725499 — The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI) · NA · recruiting
- NCT05295810 — Hypercapnia in Orthostatic Hypotension · NA · recruiting
Other James J. Peters Veterans Affairs Medical Center trials
Trials by the same sponsor.
- NCT07251491 — Psilocybin to Treat Depression in Spinal Cord Injury · Phase 1, PHASE2 · not yet recruiting
- NCT05839652 — Treatment of Orthostatic Hypotension in SCI · Phase 4 · recruiting
- NCT05422911 — Abiraterone, Enzalutamide, or Apalutamide in Castrate-sensitive Prostate Cancer. · Phase 2 · not yet recruiting
- NCT06351852 — Transdermal Administration by a Novel Wireless Iontophoresis Device · EARLY_PHASE1 · completed
- NCT05101018 — Treatment With Romosozumab Versus Denosumab to Improve Bone Mineral Density and Architecture in Subacute SCI · Phase 4 · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05960448 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by James J. Peters Veterans Affairs Medical Center
- Last refreshed: 1 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05960448.
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