Last reviewed · How we verify
NCT05295810
Hypercapnia in Orthostatic Hypotension
NA trial testing Sequential Gas Delivery in Orthostatic Hypotension in 80 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | University of Calgary |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 80 |
| Start date | 1 March 2022 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 May 2027 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Sequential Gas Delivery — full drug profile →
Conditions studied
- Orthostatic Hypotension — all drugs for Orthostatic Hypotension →
- Neurogenic Orthostatic Hypotension — all drugs for Neurogenic Orthostatic Hypotension →
Sponsor
University of Calgary
Who can join
Adults 18 to 100, any sex, with Orthostatic Hypotension or Neurogenic Orthostatic Hypotension. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The Autonomic (or "automatic") Nervous System (ANS) regulates internal processes, including control of heart rate and blood pressure (BP). When someone stands, and gravity tries to pull blood away from the brain, the ANS works to maintain BP and brain blood flow. Neurogenic Orthostatic Hypotension (NOH) occurs when our "fight-or-flight" part ("sympathetic") of the ANS fails. BP can drop a lot when upright, reducing blood flow and oxygen delivery to the brain, and this can cause symptoms of light-headedness, nausea, and fainting. One solution to help counter the effects of NOH may be to increase sympathetic activity by breathing higher levels of carbon dioxide. In healthy volunteers, small increases in the amount of inhaled carbon dioxide has been shown to increase BP in the upright position, and this improves symptoms! The objectives of the current study are to apply carbon dioxide in patients with NOH and healthy controls to: (a) evaluate the effects of breathing carbon dioxide on BP and brain blood flow, and (b) determine if a device that increases carbon dioxide while standing will work as a new therapy
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Carbon dioxide for neurogenic orthostatic hypotension in adults: a novel therapy.
Baker JR, Ranada SI, Incognito AV, Sheldon RS, et al · · 2025 · cited 3× · PMID 39374345 · DOI 10.1093/eurheartj/ehae653 -
Elevating blood pressure in neurogenic orthostatic hypotension: Investigating the efficacy and tolerability of rebreathing therapy.
Baker JR, Ranada SI, Incognito AV, Sheldon RS, et al · · 2026 · PMID 41734601 · DOI 10.1016/j.autneu.2026.103400
Verify or expand the search:
- PubMed search for NCT05295810
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05295810 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Calgary
- Last refreshed: 9 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05295810.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing