Last reviewed · How we verify
NCT05959161
Study on Brain Network Mechanism of Deep Brain Stimulation for Parkinson's Disease
trial testing DBS in Parkinson Disease in 100 participants. Not yet recruiting.
1 September 2026
Quick facts
| Lead sponsor | Tianjin Huanhu Hospital |
|---|---|
| Status | Not yet recruiting |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 1 August 2023 |
| Primary completion | 1 September 2026 |
| Estimated completion | 31 December 2026 |
Drugs / interventions tested
- DBS
Conditions studied
- Parkinson Disease — all drugs for Parkinson Disease →
- Deep Brain Stimulation — all drugs for Deep Brain Stimulation →
- Non-motor Symptoms — all drugs for Non-motor Symptoms →
Sponsor
Tianjin Huanhu Hospital
Who can join
Under 75, any sex, with Parkinson Disease or Deep Brain Stimulation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
As a surgical intervention, DBS can effectively relieve PD tremor, rigidity, bradykinesia and other symptoms. How to better screen patients suitable for DBS treatment and conduct reasonable preoperative and postoperative evaluation is crucial to judge the treatment effect and prognosis. The clinical symptom evaluation of PD patients can be divided into motor symptom evaluation and non-motor symptom evaluation. The motor symptoms of PD patients were evaluated by UPDRS III. The evaluation of non-motor symptoms in PD patients was mainly divided into three aspects: cognitive status, emotional status, and sleep status. Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used to assess the cognitive status of PD patients. The Hamilton Depression Scale (HAMD) was used to assess the patients' depression status. The Hamilton Anxiety Scale (HAMA) was used to assess the patients' anxiety status. The PD Sleep Scale 2nd version, The PD Sleep Scale 2nd version, PDSS - 2), and rem Sleep Behavior Disorder Questionnaire (sweet HK) (Rapid Eye Movement Sleep behaviors Disorder Questionnaire - Hong Kong, RBDQ - HK) to assess Sleep conditions.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Unveiling the Dominant Factors in Subthalamic Stimulation for Improving Depression in Parkinson's Disease.
Zhao G, Cheng Y, Li G, Li L, et al · · 2024 · PMID 39262097 · DOI 10.1002/mdc3.14195
Verify or expand the search:
- PubMed search for NCT05959161
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of DBS
Trials testing the same drug.
- NCT07340073 — Coordinated Reset Deep Brain Stimulation for Parkinson's Disease · Phase 1 · not yet recruiting
- NCT07376278 — Predictors of Clinical Outcomes of Deep Brain Stimulation in Parkinson's Disease · recruiting
- NCT06122675 — Cerebellar Deep Brain Stimulation for Movement Disorders in Cerebral Palsy in Children and Young Adults · NA · recruiting
- NCT05934747 — Aim 3 Particle Swarm Optimization PIGD · NA · recruiting
- NCT07325175 — Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia · NA · recruiting
Other recruiting trials for Parkinson Disease
Currently open trials in the same condition.
- NCT07399496 — Accelerated TMS for Apathy in PD · NA · recruiting
- NCT07371338 — Phase 1 Clinical Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of IPS101A in Parkinson's Disease Patients · Phase 1 · recruiting
- NCT07442370 — The Effect of Functional Rotational Exercises on Fall Risk and Mobility in Parkinson's Disease Patients · NA · recruiting
- NCT06848205 — Percept Transitions in FOG and PD · NA · recruiting
- NCT07432958 — A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (P · Phase 2 · recruiting
Other Tianjin Huanhu Hospital trials
Trials by the same sponsor.
- NCT07386015 — Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG) · recruiting
- NCT07365475 — Efficacy and Safety of Intra-Arterial Albumin as Adjunct to Mechanical Thrombectomy in Acute Ischemic Stroke · Phase 2 · not yet recruiting
- NCT07294391 — The Preliminary Efficacy and Safety of Intra-Arterial Albumin as Adjunct to Mechanical Thrombectomy in Acute Ischemic St · Phase 2 · not yet recruiting
- NCT07115511 — Combined Recanalization Therapy for Acute Large Vessel Occlusion Stroke · NA · recruiting
- NCT06621121 — A Real-world Study of Tenecteplase Versus Alteplase for Thrombolysis in Patients Within 4.5 H of Onset of Ischemic Strok · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05959161 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tianjin Huanhu Hospital
- Last refreshed: 25 July 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05959161.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing