Last reviewed · How we verify
NCT05956769
Goal-directed vs Preemptive Tranexamic Acid Administration in Total Hip Arthroplasty
NA trial testing Tranexamic Acid in Arthritis of Hip in 84 participants. Status unknown.
30 November 2024
Quick facts
| Lead sponsor | Konkuk University Medical Center |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | diagnostic |
| Enrollment | 84 |
| Start date | 1 February 2024 |
| Primary completion | 30 November 2024 |
| Estimated completion | 31 December 2024 |
| Sites | 2 locations across South Korea |
Drugs / interventions tested
- Tranexamic Acid (Tranexamic Acid) — full drug profile →
- thromboelastography — full drug profile →
- Placebo
Conditions studied
- Arthritis of Hip — all drugs for Arthritis of Hip →
Sponsor
Konkuk University Medical Center
Who can join
19 and older, any sex, with Arthritis of Hip. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The present study is a multi-center randomized prospective placebo-controlled non-inferiority trial. The study's primary objective is to compare the amounts of postoperative bleeding using two different TXA administration strategies: empirical TXA administration vs. viscoelastic test-based Goal-directed vs Preemptive Tranexamic Acid Administration in total hip arthroplasty. The secondary objectives include comparing the incidents of hyper-fibrinolysis, thromboembolic complications, and postoperative seizures. Researchers assumed that goal-directed tranexamic acid (TXA) administration using viscoelastic field tests would not be inferior to the empirical TXA administration strategy in reducing postoperative bleeding and hyper-fibrinolysis. It also would be beneficial in lowering TXA-induced thromboembolic complications and seizures.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Viscoelastic haemostatic assays to guide therapy in elective surgery: an updated systematic review and meta-analysis.
Dias JD, Levy JH, Tanaka KA, Zacharowski K, et al · · 2025 · cited 6× · PMID 39544008 · DOI 10.1111/anae.16463
Verify or expand the search:
- PubMed search for NCT05956769
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Tranexamic Acid
Trials testing the same drug.
- NCT07501884 — REDUCER Trial (TXA in Urethroplasty) · Phase 4 · not yet recruiting
- NCT07460518 — Tranexamic Acid for Bleeding Reduction During TURP Surgery · Phase 4 · not yet recruiting
- NCT07390799 — Prophylactic Tranexamic Acid in Low-Risk Repeat Cesarean Delivery: A Randomized Controlled Trial · NA · not yet recruiting
- NCT07078942 — Prophylactic Intravenous Tranexamic Acid on Perioperative Blood Loss in Pregnant Women Undergoing Cesarean Section · Phase 4 · not yet recruiting
- NCT07263841 — Comparison of Effectiveness of Tranexamic Acid Mesotherapy Versus Glutathione Mesotherapy in Post Burn Facial Hyperpigme · Phase 2 · active not recruiting
Other recruiting trials for Arthritis of Hip
Currently open trials in the same condition.
- NCT05957822 — Goal-directed vs Preemptive Tranexamic Acid Administration in Non-cardiac Surgery · Phase 4 · recruiting
- NCT05366712 — Nexus Evaluation Primary Trident II Uncemented Shell · NA · active not recruiting
Other Konkuk University Medical Center trials
Trials by the same sponsor.
- NCT06637943 — Comparison of the Diagnosis Time of VET and SCL in Patients With Intraoperative Coagulopathy · not yet recruiting
- NCT06144112 — Fibrinogen Concentrates Versus Cryoprecipitate in Liver Transplant Surgery · Phase 4 · not yet recruiting
- NCT06664320 — Mild ANH on Pre-bypass Coagulation Function During Cardiac Surgery · NA · not yet recruiting
- NCT06574594 — Effect of MTX Discontinuation on Shingrix Response in RA · NA · recruiting
- NCT06144099 — Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Non-cardiac Surgery · Phase 4 · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05956769 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Konkuk University Medical Center
- Last refreshed: 2 January 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05956769.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing