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NCT05952921: HOCl-Post-AA
Comparison of the Effectiveness of Hypochlorous Acid and Chlorhexidine as a Post-surgical Antimicrobial Agent
NA trial testing Mouthwash in Periodontal Diseases in 32 participants. Completed in 15 December 2019.
1 December 2019
Quick facts
| Lead sponsor | Universidad El Bosque, Bogotá |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 32 |
| Start date | 10 July 2019 |
| Primary completion | 1 December 2019 |
| Estimated completion | 15 December 2019 |
| Sites | 1 location across Colombia |
Drugs / interventions tested
- Mouthwash
- Chlorhexidine (CHLORHEXIDINE) — full drug profile →
Conditions studied
- Periodontal Diseases — all drugs for Periodontal Diseases →
- Chronic Periodontitis — all drugs for Chronic Periodontitis →
- Microbial Colonization — all drugs for Microbial Colonization →
Sponsor
Universidad El Bosque, Bogotá — full company profile →
Who can join
Adults 20 to 60, any sex, with Periodontal Diseases or Chronic Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the study is to evaluate the effectiveness of Hypochlorous Acid and Chlorhexidine as postsurgical antimicrobial agents in the treatment of severe chronic periodontal disease. The selected patients will be randomly divided into two groups of 16 each. Subjects in group I will undergo scaling and surgical root planing and will use mouthrinse with 0.05% HOCl for 7 days, after this they will mouthwash with 0.025% HOCl until day 21 and Subjects in group II will undergo scaling and surgical root planing followed by a rinse with CHX 0.2% for 7 days, after this they will mouthwash with 0.12% CHX until day 21. Null Hypothesis: There are no significant differences between hypochlorous acid and chlorhexidine in reducing plaque formation at 7, 21 and 90 days of evaluation. There are no significant differences between HOCl and CHX in the elimination or reduction of periodontopathogenic microorganisms at 7, 21 and 90 days. Alternative hypotheses: There are significant differences between hypochlorous acid and chlorhexidine in reducing plaque formation at 7, 21 and 90 days of evaluation. There are significant differences between HOCl and CHX in the elimination or reduction of periodontopathogenic microorganisms at 7, 21 and 90 days.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Hypochlorous Acid as a Potential Postsurgical Antimicrobial Agent in Periodontitis: A Randomized, Controlled, Non-Inferiority Trial.
Plata JC, Díaz-Báez D, Delgadillo NA, Castillo DM, et al · · 2023 · cited 1× · PMID 37627732 · DOI 10.3390/antibiotics12081311
Verify or expand the search:
- PubMed search for NCT05952921
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Mouthwash
Trials testing the same drug.
- NCT07029438 — Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis · Phase 4 · completed
- NCT04644900 — Effect of Chewing Gum and Mouthwash Before Operation on Sore Throat After General Anesthesia With a Laryngeal Mask · NA · unknown
- NCT03467061 — The Effect of Dietary Nitrate on the Oral Microbiome · NA · completed
Other recruiting trials for Periodontal Diseases
Currently open trials in the same condition.
- NCT07358104 — Efficacy of Camel Whey Protein and Camel Whey Protein Nanoparticles for Treating Intra-bony Periodontal Defects · NA · active not recruiting
- NCT07312045 — HALP Score, Blood-Based Inflammatory Indices, and Salivary MMP-8 in Periodontal Disease and Healing After Non-Surgical T · recruiting
- NCT07384221 — Periodontal Status and Disease Severity in Pemphigus Vulgaris Patients · recruiting
- NCT07530978 — ORAL HYGIENE, PERIODONTAL STATUS AND QUALITY OF LIFE · recruiting
- NCT06848790 — Interdental Hygiene Methods in Young Adults · NA · recruiting
Other Universidad El Bosque, Bogotá trials
Trials by the same sponsor.
- NCT06690008 — Fluoride Caries-control Effectiveness/Feasibility in Children · NA · completed
- NCT04666597 — Pandemic-adapted Caries Care Multicentre Single-group Interventional Study · completed
- NCT03354338 — Amoxicillin to Prevent Bacteria and Inflammatory Biomarkers After Intensive Periodontal Therapy · Phase 2 · unknown
- NCT03174756 — HYPOCHLOROUS ACID SUBSTANTIVITY AS ANTIPLAQUE AGENT (HOCl-SAP) · Phase 2 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05952921 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universidad El Bosque, Bogotá
- Last refreshed: 19 July 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05952921.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing