Last reviewed · How we verify
NCT05944575
Effect of taVNS on Heart Rate in Persistent Atrial Fibrillation
NA trial testing active taVNS in Atrial Fibrillation, Persistent in 30 participants. Status unknown.
31 July 2025
Quick facts
| Lead sponsor | Burrell College of Osteopathic Medicine |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 7 August 2023 |
| Primary completion | 31 July 2025 |
| Estimated completion | 31 July 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- active taVNS
- sham-taVNS
Conditions studied
- Atrial Fibrillation, Persistent — all drugs for Atrial Fibrillation, Persistent →
Sponsor
Burrell College of Osteopathic Medicine
Who can join
18 and older, any sex, with Atrial Fibrillation, Persistent. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to investigate the effects of non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) in patients with persistent atrial fibrillation. taVNS is a treatment through which a small electrical current is applied to a specific location of the left ear. The main question to answer is whether taVNS will reduce the heart rate in patients with persistent atrial fibrillation. After appropriate training, participants will self-administer taVNS for 30 minutes every day for two weeks. During one of the two weeks (randomized order), the clip electrode, delivering the electrical current will be attached to the cymba conchae of the left ear, while during the other week the clip electrode will be attached to the lobule of the left ear. During both weeks, the electrocardiogram (ECG) will be monitored continuously through a small ECG patch that is placed on the chest. Participants will meet with the investigators at the beginning of the study, after 7 days and at the end of the study (after 14 days). Researchers will compare the ECG obtained during the two weeks and evaluate if the heart rate differs between the two study weeks.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Patient-reported effectiveness of strategies to convert paroxysmal atrial fibrillation to sinus rhythm in the home setting - a community-based participatory research approach.
Stauss HM, Morris AT, Brinza J, Eniola B, et al · · 2026 · PMID 41612208 · DOI 10.1186/s12872-025-05462-5
Verify or expand the search:
- PubMed search for NCT05944575
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of active taVNS
Trials testing the same drug.
- NCT06127550 — taVNS for Letter Learning in Dyslexia · NA · suspended
- NCT05852379 — Transcutaneous Auricular Vagus Nerve Stimulation in Spinal Cord Injury · NA · unknown
Other recruiting trials for Atrial Fibrillation, Persistent
Currently open trials in the same condition.
- NCT06833138 — Atrioventricular Node Ablation and Conduction System Pacing in Patients With Well Controlled Permanent Atrial Fibrillati · NA · recruiting
- NCT06654401 — Electrical Cardioversion As a Predictor in Postoperative Preservation of Sinus Rhythm · NA · recruiting
- NCT06578793 — Comparison of Catheter Plus Marshall Vein Ablation vs. Catheter Ablation Alone in Persistent AF With Heart Failure · NA · recruiting
- NCT06249347 — Left Roof Linear, Mitral Isthmus Linear and Left Anterior Septal Linear Ablation for Non-paroxysmal AF: PROMISED Trial. · NA · recruiting
- NCT06172699 — Assert-IQ Implantable Cardiac Monitor (ICM) Post Market Study · active not recruiting
Other Burrell College of Osteopathic Medicine trials
Trials by the same sponsor.
- NCT05243303 — Augmenting Standard-of-care Treatment of Plaque Psoriasis by Neuromodulation · NA · unknown
- NCT04926415 — Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Obesity and Insulin Resistance · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05944575 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Burrell College of Osteopathic Medicine
- Last refreshed: 14 July 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05944575.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing